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Documenti

T7697

Sigma-Aldrich

I-OMe-Tyrphostin AG 538

solid

Sinonimo/i:

α-Cyano-(3-methoxy-4-hydroxy-5-iodocinnamoyl)-(3′,4′-dihydroxyphenyl)ketone, I-OMe-AG 538

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About This Item

Formula empirica (notazione di Hill):
C17H12INO5
Peso molecolare:
437.19
Numero MDL:
MFCD03453582
Codice UNSPSC:
12352203
ID PubChem:
24278758
NACRES:
NA.77

Forma fisica

solid

Livello qualitativo

100

Solubilità

DMSO: 50 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

COc1cc(cc(I)c1O)\C=C(/C#N)C(=O)c2ccc(O)c(O)c2

InChI

1S/C17H12INO5/c1-24-15-6-9(5-12(18)17(15)23)4-11(8-19)16(22)10-2-3-13(20)14(21)7-10/h2-7,20-21,23H,1H3/b11-4+
HSRMHXWCTRFVHK-NYYWCZLTSA-N

Informazioni sul gene

human ... IGF1(3479) , IGF1R(3480)

Applicazioni

I-OMe-Tyrphostin AG 538 has been used as a cell signaling inhibitor in PC-1 cell lines. It has also been used in high throughput screening assays for IGF1R inhibitors.

Azioni biochim/fisiol

Insulin growth factor 1 (IGF-1) receptor protein tyrosine kinase inhibitor.

Caratteristiche e vantaggi

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Nota sulla preparazione

I-OMe-Tyrphostin AG 538 is soluble in DMSO at 50 mg/ml.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Sara M Garrett et al.
PloS one, 14(11), e0225422-e0225422 (2019-11-26)
Type 2 insulin-like growth factor (IGF-II) levels are increased in fibrosing lung diseases such as idiopathic pulmonary fibrosis (IPF) and scleroderma/systemic sclerosis-associated pulmonary fibrosis (SSc). Our goal was to investigate the contribution of IGF receptors to IGF-II-mediated fibrosis in these
Haifeng Geng et al.
PloS one, 6(12), e29504-e29504 (2012-01-05)
Small molecules have been identified as potential therapeutic agents for lysosomal storage diseases (LSDs), inherited metabolic disorders caused by defects in proteins that result in lysosome dysfunctional. Some small molecules function assisting the folding of mutant misfolded lysosomal enzymes that
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
Mahsa Hamzeh et al.
The Journal of endocrinology, 209(1), 55-64 (2011-01-12)
Androgens are the primary regulators of epididymal structure and functions. In the classical view of androgen action, binding of androgen to the intracellular androgen receptor (AR) produces the receptor-steroid complex that has high affinity for DNA response elements and regulates

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