RAB0659
Human FOLR1 / Folate Receptor Alpha ELISA Kit
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About This Item
Codice UNSPSC:
41116158
NACRES:
NA.84
Prodotti consigliati
Reattività contro le specie
human
Confezionamento
kit of 96 wells (12 strips x 8 wells)
tecniche
ELISA: suitable
input
sample type cell culture supernatant(s)
sample type plasma
sample type serum
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.1 ng/mL
standard curve range: 0.102-25 ng/mL
Metodo di rivelazione
colorimetric
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... FOLR1(2348)
Descrizione generale
The antibody pair provided in this kit recognizes human Folate Receptor Alpha.
The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4. The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes. Folr1 is expressed in placenta, kidney tubules and choroid plexus.
The folate receptor 1 (FOLR1) gene is mapped to human chromosome 11q13.4. The gene codes for a glycosylphosphatidylinositol protein that is attached to cell membranes. Folr1 is expressed in placenta, kidney tubules and choroid plexus.
Applicazioni
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Azioni biochim/fisiol
Folate receptor 1 (FOLR1) plays a vital role in folate transport across the blood–brain barrier through the choroid plexus. It is also essential for neural tube closure during embryogenesis. Mutation in the gene leads to the development of cerebral folate deficiency in a few families. Overexpression of the gene has been observed in some epithelial malignancies including medulloblastoma, ovarian, lung and breast carcinomas. FOLR1 acts as a potential biomarker and therapeutic target for medulloblastoma.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Met. Corr. 1
Codice della classe di stoccaggio
8B - Non-combustible corrosive hazardous materials
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Differential expression of folate receptor 1 in medulloblastoma and the correlation with clinicopathological characters and target therapeutic potential.
Liu H, et al.
Oncotarget, 8(14), 23048-23048 (2017)
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Watkins D and Rosenblatt DS
Journal of inherited metabolic disease, 35(4), 665-670 (2012)
Congenital null mutations of the FOLR1 gene: a progressive neurologic disease and its treatment.
Cario H, et al.
Neurology, 73(24), 2127-2129 (2009)
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