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T4446

SAFC

N-Acetyl-L-tyrosine

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About This Item

Formula condensata:
4-(HO)C6H4CH2CH(NHCOCH3)CO2H
Numero CAS:
537-55-3
Peso molecolare:
223.23
Beilstein:
2697172
Numero CE:
208-671-3
Numero MDL:
MFCD00037190
Codice UNSPSC:
12352209
NACRES:
NA.26

Origine biologica

non-animal source

Saggio

≥98.5%

Stato

crystalline powder

Produttore/marchio commerciale

Ajinomoto

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, heavy metals, tested

Punto di fusione

149-152 °C (lit.)

Solubilità

H2O: 25 mg/mL

applicazioni

pharmaceutical (small molecule)

Stringa SMILE

CC(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C11H13NO4/c1-7(13)12-10(11(15)16)6-8-2-4-9(14)5-3-8/h2-5,10,14H,6H2,1H3,(H,12,13)(H,15,16)/t10-/m0/s1
CAHKINHBCWCHCF-JTQLQIEISA-N

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Descrizione generale

To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to documentation for this product requires a confidentiality disclosure agreement.

Applicazioni

L-Tyrosine is a non-essential amino acid. It can be used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. N-Acetyl-L-tyrosine is an acetylated derivative of the essential amino acid L-tyrosine with reported improved nutritional properties.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
CDBF5621
CDBF5620
CDBD1772
CDBD1773
CDBC8188

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Supelco

PHR1097

L-tirosina

Gly-Tyr

Sigma-Aldrich

G3502

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N-acetil-L-cisteina Sigma Grade, ≥99% (TLC), powder

Sigma-Aldrich

A7250

N-acetil-L-cisteina

L-tirosina reagent grade, ≥98% (HPLC)

Sigma-Aldrich

T3754

L-tirosina

L-tirosina

SAFC

T4321

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L-Tyrosine disodium salt hydrate BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

Sigma-Aldrich

T1145

L-Tyrosine disodium salt hydrate

L John Hoffer et al.
JPEN. Journal of parenteral and enteral nutrition, 27(6), 419-422 (2003-11-19)
N-acetyl-L-tyrosine (NAT) is commonly used in place of tyrosine in parenteral nutrition, but human studies carried out to date indicate considerable amounts of it are excreted unchanged in the urine. NAT retention has not been well studied in parenterally fed
A R Butler et al.
Nitric oxide : biology and chemistry, 4(5), 472-482 (2000-10-06)
By the observation of chemically induced dynamic nuclear polarization in (15)N NMR spectroscopy it has been shown that nitration of N-acetyltyrosine, even under acidic conditions, is largely a radical process. In the alkaline reaction of tyrosine with peroxynitrite the main
Rakesh Kumar et al.
European journal of medicinal chemistry, 42(4), 503-510 (2006-12-26)
The development of type 2 diabetes in obese individuals is linked to lipid accumulation in non-adipose tissues. A series of N-acetyl-L-tyrosine derivatives were synthesized and evaluated for PPAR transactivation. Compounds 4d and 4f were found to show better PPARalpha transactivation
[Recording the delta-pH-generating biochemical reactions by light-addressed sensors with Ta2O5 dielectrics].
A N Reshetilov et al.
Doklady Akademii nauk, 342(5), 700-702 (1995-06-01)
M Sharma et al.
Chemico-biological interactions, 108(3), 171-185 (1998-04-07)
Dityrosine (DT) was isolated in a single-step by reversed-phase HPLC in 25% yield from enzyme-catalyzed oxidation of N-acetyl tyrosine followed by deacetylation. The isolated product was characterized by 1H NMR. A three-step chromatographic procedure was reported to facilitate the preparation
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