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T4143

Sigma-Aldrich

Triamterene

≥99%

Sinonimo/i:

2,4,7-Triamino-6-phenylpteridine, 6-Phenyl-2,4,7-pteridinetriamine

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About This Item

Formula empirica (notazione di Hill):
C12H11N7
Numero CAS:
396-01-0
Peso molecolare:
253.26
Numero CE:
206-904-3
Numero MDL:
MFCD00006708
Codice UNSPSC:
12352200
ID PubChem:
24277877
NACRES:
NA.77

Saggio

≥99%

Solubilità

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 1.2 mg/mL
DMSO: soluble 5.4 mg/mL
H2O: insoluble

Ideatore

Wellspring

Stringa SMILE

Nc1nc(N)c2nc(-c3ccccc3)c(N)nc2n1

InChI

1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19)
FNYLWPVRPXGIIP-UHFFFAOYSA-N

Informazioni sul gene

human ... SCNN1A(6337) , SCNN1B(6338) , SCNN1G(6340)

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Applicazioni

Triamterene has been used to study its effects on urokinase receptor (uPAR) induction in podocytes under in vitro conditions2. Triamterene has also been identified as an activator compound from a LOPAC library screen using a fluorogenic α-glucosidase assay3.

Azioni biochim/fisiol

Weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Caratteristiche e vantaggi

This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

200 mg of triamterene is soluble in 4 ml of warm formic acid and yields a clear, yellow-green solution. Triamterene is also soluble in DMSO (5.4 mg/ml), and in 45% (w/v) aqueous 2-hydroxypropyl-β-cyclodextrin (1.2 mg/ml). However, it is insoluble in water.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Bumetanide ≥98%

Sigma-Aldrich

B3023

Bumetanide

Balraj S Heran et al.
The Cochrane database of systematic reviews, (1)(1), CD008167-CD008167 (2010-01-22)
Potassium-sparing diuretics, which block the epithelial sodium channel (ENaC), are widely prescribed for hypertension as a second-line drug in patients taking other diuretics (e.g. thiazide diuretics) and much less commonly prescribed as monotherapy. Therefore, it is essential to determine the
Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(6), 995-1002 (2008-03-07)
The role of breast cancer resistance protein (BCRP/ABCG2) in limiting the brain and testis penetration of xenobiotic compounds in the blood-brain and -testis barriers was investigated using Bcrp(-/-) mice. Tissue/plasma concentration ratios in the brain (K(p,brain)) and testis (K(p,testis)) obtained
Zhuomin Zhang et al.
The Analyst, 133(9), 1187-1194 (2008-08-19)
In competition sports, a diuretic is a substance widely prohibited by the World Anti-Doping Agency (WADA). In this paper, a sensitive, rapid and convenient analytical method for the determination of acidic [furosemide (FUROS) and bumetanide (BUMET)] and basic [triamterene (TRIAM)]
Yiqun Wu et al.
Clinical drug investigation, 31(11), 769-777 (2011-06-16)
A fixed-dose combination (FDC) of four compounds, hydrochlorothiazide 12.5 mg, triamterene 12.5 mg, dihydralazine 12.5 mg and reserpine 0.1 mg (HTDR), is widely used as an antihypertensive treatment in China. Although HTDR has been used in China for more than
Ali Asghar Ensafi et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 24(11), 1449-1454 (2008-11-11)
A square-wave voltammetric procedure for the electroanalytical determination of losartan and triamterene in Britton-Robinson buffer (pH 3.0, 0.1 mol L(-1)) as a supporting electrolyte containing 30 ng mL(-1) of copper ions was developed. Opposite to the case of triamterene, losartan
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