F4381

Furosemide

≥98% (HPLC), powder, NKCC symporter inhibitor

• Sinonimo/i: 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
• Formula empirica (notazione di Hill): C₁₂H₁₁ClN₂O₅S
• Numero CAS: 54-31-9
• Peso molecolare: 330.74
• Numero CE: 200-203-6
• Numero MDL: MFCD00010549
• Codice UNSPSC: 12352200
• ID PubChem: 24277714
• NACRES: NA.77

Proprietà

• Nome del prodotto: Furosemide,
• Origine biologica: synthetic (organic)
• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Stato: powder
• Punto di fusione: 220 °C (dec.) (lit.)
• Solubilità: acetone: 50 mg/mL, clear to slightly hazy, colorless to yellow
• Ideatore: Sanofi Aventis
• Temperatura di conservazione: room temp
• Stringa SMILE: NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl
• InChI: 1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19); ZZUFCTLCJUWOSV-UHFFFAOYSA-N
• Informazioni sul gene: human ... ALB(213) , CYP1A2(1544) , SLC12A1(6557)

Descrizione

Descrizione generale

Furosemide is a an ototoxic high-ceiling diuretic.

Applicazioni

Furosemide has been used:

• to investigate the influence of timing of dexamethasone administration on auditory hair cell survival in mice
• to study its effect on intracranial pressure (ICP) after subcutaneous administration in rats
• as a stimulant for renin release and subsequent increase in plasma angiotensin II (ANG II)

Azioni biochim/fisiol

"High ceiling" diuretic that strongly affects renal tubular action by increasing renal blood flow; antihypertensive.

Furosemide can block the Na⁺/K⁺/2Cl^- co-transporter in the ascending thick loop of Henle. It can enhance the synthesis of intrarenal prostaglandin. It enhances its ototoxicity in animals when used along with kanamycin. Furosemide is linked with thiamine insufficiency in individuals with heart failure.

Inhibits ion co-transport in the kidney.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H360FD
• Consigli di prudenza: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classi di pericolo: Acute Tox. 4 Oral - Repr. 1B
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges