T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• Sinonimo/i: 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• Formula empirica (notazione di Hill): C₂₉H₅₀O₂
• Numero CAS: 59-02-9
• Peso molecolare: 430.71
• Beilstein: 4712525
• Numero CE: 200-412-2
• Numero MDL: MFCD00072045
• Codice UNSPSC: 12352205
• eCl@ss: 34058016
• ID PubChem: 24900154
• NACRES: NA.79

Proprietà

• Origine biologica: vegetable oil
• Livello qualitativo: 200
• Tipo: Type V
• Forma fisica: viscous liquid
• Attività specifica: ~1000 IU/g
• Colore: clear yellow to red
• Indice di rifrazione: n20/D 1.505 (lit.)
• P. eboll.: 200-220 °C/0.1 mmHg (lit.)
• Densità: 0.95 g/mL at 25 °C (lit.)
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1; GVJHHUAWPYXKBD-IEOSBIPESA-N

Descrizione

Descrizione generale

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Applicazioni

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

Azioni biochim/fisiol

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Confezionamento

Packaged under argon in a sealed ampule.

Altre note

Mixed constitutional (α, β, γ, δ) isomers.

Qualità

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

Avvertenza

Subject to air oxidation.

Proprietà fisiche

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): 230.0 °F - closed cup
• Punto d’infiammabilità (°C): 110 °C - closed cup
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)