Passa al contenuto
Merck
Tutte le immagini(3)

Key Documents

View All Documentation

T1270

Sigma-Aldrich

Thiamine hydrochloride

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sinonimo/i:

Aneurine hydrochloride, Vitamin B1 hydrochloride

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(3)

About This Item

Formula empirica (notazione di Hill):
C12H17ClN4OS · HCl
Numero CAS:
67-03-8
Peso molecolare:
337.27
Beilstein:
3851771
Numero CE:
200-641-8
Numero MDL:
MFCD00012780
Codice UNSPSC:
12352207
eCl@ss:
34058006
ID PubChem:
24899952
NACRES:
NA.75

Origine biologica

synthetic (organic)

Livello qualitativo

200

Nome Commerciale

BioReagent

Saggio

≥99.0% (HPLC)

Forma fisica

powder

PM

Mw 337.27 g/mol

tecniche

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

Colore

white

Punto di fusione

250 °C (dec.) (lit.)

Solubilità

H2O: 50 mg/mL, clear, colorless

applicazioni

agriculture

Stringa SMILE

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1
DPJRMOMPQZCRJU-UHFFFAOYSA-M

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

Thiamine or Vitamin B1 is a positively charged and essential constituent for all tissues. It is present at higher levels in skeletal muscles, liver, kidney, heart, and brain. Thiamine is composed of a pyrimidine ring linked to a thiazole ring via a methylene bridge.

Applicazioni

Thiamine hydrochloride has been used as a component:
  • of the vitamin-concentrated stock solution for the preparation of Hv-Ca medium for culturing Haloferax volcanii
  • of the tris-acetate-phosphate (TAP) medium for culturing Chlamydomonas nivalis
  • of modified Bold 3N medium for culturing Chlorella minutissima

Azioni biochim/fisiol

Thiamine is converted to thiamine diphosphate post-movement into the cellular membranes by thiamine diphosphokinase. Thiamine diphosphate, an active cofactor is essential for the mechanism of many enzymes involved in the citric acid cycle, the glycolytic pathway, the degradation of branched-chain amino acids, and the pentose phosphate pathway. Thiamine is involved in converting food into energy required for functioning the central and peripheral nervous systems. Lower levels of this vitamin are associated with delirium, Wernicke′s encephalopathy, and Wernicke-Korsakoff syndrome. Thiamine hydrochloride is required to support energy metabolism and amino acid synthesis in cultured cells. It is present in many classical and serum-free formulations.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319

Classi di pericolo

Eye Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 7

1 of 7

Biotina powder, BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥99%

Sigma-Aldrich

B4639

Biotina

myo-Inositol ≥99% (GC), BioReagent

Sigma-Aldrich

I7508

myo-Inositol

Thiamine HCl (Vitamin B1) solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-014

Thiamine HCl (Vitamin B1) solution

(−)-Riboflavina BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

Sigma-Aldrich

R9504

(−)-Riboflavina

D-Pantothenic acid hemicalcium salt BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture

Sigma-Aldrich

P5155

D-Pantothenic acid hemicalcium salt

Pyridoxine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

P9755

Pyridoxine hydrochloride

Pyridoxine ≥98%

Sigma-Aldrich

P5669

Pyridoxine

A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst
Lei M, et al.
Tetrahedron Letters, 51(32), 4186-4188 (2010)
Cinzia Fino et al.
MicrobiologyOpen, 9(8), e1064-e1064 (2020-06-20)
Antibiotic-tolerant persisters are often implicated in treatment failure of chronic and relapsing bacterial infections, but the underlying molecular mechanisms have remained elusive. Controversies revolve around the relative contribution of specific genetic switches called toxin-antitoxin (TA) modules and global modulation of
Roshali T de Silva et al.
Microbiology (Reading, England), 167(2) (2021-01-19)
Some microbes display pleomorphism, showing variable cell shapes in a single culture, whereas others differentiate to adapt to changed environmental conditions. The pleomorphic archaeon Haloferax volcanii commonly forms discoid-shaped ('plate') cells in culture, but may also be present as rods
Joseph E Kerschner et al.
Archives of otolaryngology--head & neck surgery, 135(1), 33-39 (2009-01-21)
To investigate genetic differences in middle ear mucosa (MEM) with nontypeable Haemophilus influenzae (NTHi) infection. Genetic upregulation and downregulation occurs in MEM during otitis media (OM) pathogenesis. A comprehensive assessment of these genetic differences using the techniques of complementary DNA
N Milne et al.
FEMS yeast research, 20(2) (2019-09-27)
We present a teaching protocol suitable for demonstrating the use of EasyClone and CRISPR/Cas9 for metabolic engineering of industrially relevant yeasts Saccharomyces cerevisiae and Yarrowia lipolytica, using β-carotene production as a case study. The protocol details all steps required to
Visualizza tutti i documenti correlati

Articoli

Thiamine in Cell Culture

How thiamine and other cell culture components affect the performance of serum-free, protein-free cell culture systems used for biomanufacturing heterologous proteins including monoclonal antibodies. The page introduces the in vitro chemistry and biochemistry of thiamine.

Nucleotide Synthesis in Cancer Cells

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.