R9504

(−)-Riboflavina

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

• Sinonimo/i: Lattoflavina, Vitamina B₂, Vitamina G
• Formula empirica (notazione di Hill): C₁₇H₂₀N₄O₆
• Numero CAS: 83-88-5
• Peso molecolare: 376.36
• Beilstein: 97825
• Numero CE: 201-507-1
• Numero MDL: MFCD00005022
• Codice UNSPSC: 12352205
• eCl@ss: 34058005
• ID PubChem: 24899415
• NACRES: NA.75

Proprietà

• Origine biologica: Eremothecium ashbyii
• Livello qualitativo: 200
• Nome Commerciale: BioReagent
• Saggio: ≥98%
• Stato: powder
• PM: M_w 376.36 g/mol
• tecniche: cell culture | insect: suitable; cell culture | mammalian: suitable
• Colore: yellow to orange
• Punto di fusione: 290 °C (dec.) (lit.)
• Solubilità: 0.1 M NaOH: 10 mg/mL, clear, yellow to orange
• Temperatura di conservazione: room temp
• Stringa SMILE: CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1
• InChI: 1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1; AUNGANRZJHBGPY-SCRDCRAPSA-N

Descrizione

Descrizione generale

Riboflavin supports cell growth and metabolism, aiding researchers in R&D. In cell culture, it is often found as a key ingredient in media formulations. Cancer researchers study its impact on oxidative stress responses. Stem cell researchers value its role in maintaining pluripotency.


Riboflavin is an essential vitamin soluble in water. Milk and eggs are found to be its major sources. Riboflavin is usually bound to enzymes in all tissues. During riboflavin localization in plasma, it is bound to albumin and specific immunoglobulins.

Applicazioni

(-)-Riboflavin has been used to administer intraperitoneally to experimental mice to study its protective role in stroke in middle cerebral artery occlusion. It has also been used with Krebs′ solution, to model ischemia-like conditions in vitro.

Azioni biochim/fisiol

Riboflavin serves as a precursor for the active enzyme cofactors riboflavin 5′-monophosphate (also called flavin mononucleotide or FMN) and flavin adenine dinucleotide (FAD). Riboflavin deficiency in the diet results in a well-defined syndrome known as ariboflavinosis, having symptoms including cheilosis, angular stomatitis, glossitis, keratitis, and seborrhoeic dermatitis. Riboflavin exhibits protective effects against tumor development and cardiovascular disease. Its deficiency often affects metabolism involving redox reactions. Riboflavin is found essential for iron absorption, gastrointestinal development, neurogenesis, corneal vascularization and corneal opacity.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)