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Merck
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Documenti fondamentali

T0577

Sigma-Aldrich

D-δ-Tocotrienol

from rice, ≥65% (GC)

Sinonimo/i:

(R-(E,E))-3,4-Dihydro-2,8-dimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2H-1-benzopyran-6-ol

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About This Item

Formula empirica (notazione di Hill):
C27H40O2
Numero CAS:
25612-59-3
Peso molecolare:
396.61
Codice UNSPSC:
12352205
NACRES:
NA.79

Origine biologica

rice

Livello qualitativo

100

Stato

liquid

Concentrazione

≥65% (GC)

Colore

yellow to orange

Temperatura di conservazione

−20°C

InChI

1S/C27H40O2/c1-20(2)10-7-11-21(3)12-8-13-22(4)14-9-16-27(6)17-15-24-19-25(28)18-23(5)26(24)29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1
ODADKLYLWWCHNB-LDYBVBFYSA-N

Descrizione generale

D-δ-Tocotrienol is a bioavailable isomer of vitamin E and has farnesyl side chain. Palm oil is rich in δ-Tocotrienol.

Azioni biochim/fisiol

D-δ-Tocotrienol suppresses ras sarcoma (Ras) protein levels. It elicits anti-proliferative functionality in melanoma cells by halting cell cycle and favoring apoptosis. δ-Tocotrienol is cytotoxic to human lung adenocarcinoma and glioblastoma cancer cells. δ-Tocotrienol possesses anti-inflammatory, antidiabetic and neuroprotective functionality. It is an effective hypocholesterolemic agent and an inhibitor of lipid peroxidation.
Tocotrienols are widely utilized for their strong antioxidant properties. The various isoforms of tocotrienols differ in their methyl substitution in the chromanol head. δ-tocotrienol, effectively blocks cleavage of SREBPs, ultimately decreasing the amount of cholesterol synthesized in the liver.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
MKCP0148
MKCL4007
MKCK2399
MKCB9287
MKBV6008V

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(+)-γ-Tocopherol analytical standard

Supelco

47785

(+)-γ-Tocopherol

δ-Tocopherol analytical standard

Supelco

47784

δ-Tocopherol

(±)-α-tocoferolo ≥95.5%

Sigma-Aldrich

258024

(±)-α-tocoferolo

(±)-α-tocoferolo synthetic, ≥96% (HPLC)

Sigma-Aldrich

T3251

(±)-α-tocoferolo

(±)-α-tocoferolo analytical standard

Supelco

47783

(±)-α-tocoferolo

A review of characterization of tocotrienols from plant oils and foods
Ahsan H, et al.
Journal of Chemical Biology, 8(2), 45-59 (2015)
Cytotoxicity and apoptotic activities of alpha-, gamma-and delta-tocotrienol isomers on human cancer cells
Lim SW, et al.
BMC Complementary and Alternative Medicine, 14(1), 469-469 (2014)
The Impact of delta-Tocotrienol and Geranylgeraniol on Cell Cycle Progression and Apoptosis in Human and Murine Melanoma Cells
Fernandes NV, et al.
Faseb Journal (2010)
Kazim Husain et al.
Molecular cancer therapeutics, 10(12), 2363-2372 (2011-10-06)
The NF-κB transcription factor functions as a crucial regulator of cell survival and chemoresistance in pancreatic cancer. Recent studies suggest that tocotrienols, which are the unsaturated forms of vitamin E, are a promising class of anticancer compounds that inhibit the
Jinghai Chen et al.
Circulation, 123(6), 584-593 (2011-02-02)
Omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid) from fish oil ameliorate cardiovascular diseases. However, little is known about the effects of ω-3 polyunsaturated fatty acids on cardiac fibrosis, a major cause of diastolic dysfunction and heart failure. The
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