SRP8040
LAG-3 (human): FC (human)
recombinant, expressed in CHO cells, >99% (SDS-PAGE)
Sinonimo/i:
FDC Protein, Lymphocyte activation gene-3, PC cell-derived growth factor
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in CHO cells
Saggio
>99% (SDS-PAGE)
Stato
liquid
PM
~80 kDa by SDS-PAGE
Confezionamento
pkg of 50 μg
Concentrazione
≥0.2 mg/mL
Impurezze
<0.1 EU/μg endotoxin, tested
Colore
clear
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... LAG3(3902)
Descrizione generale
LAG3 (lymphocyte activation gene 3) is an inhibitory CD4 (cluster of differentiation)-related molecule, and is expressed by activated CD4+ and CD8+ T cells.
Azioni biochim/fisiol
LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) both in vivo and in vitro. HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4+ and CD8+ T cells, and this is linked with disease progression. In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.
Stato fisico
Solution in PBS.
Altre note
The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer.
Matsuzaki J et al
Proceedings of the National Academy of Sciences of the USA, 107(17), 7875-7880 (2010)
Ching-Tai Huang et al.
Immunity, 21(4), 503-513 (2004-10-16)
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The Journal of investigative dermatology, 134(7), 1893-1902 (2014-01-21)
Plasmacytoid dendritic cells (pDCs) at tumor sites are often tolerogenic. Although pDCs initiate innate and adaptive immunity upon Toll-like receptor (TLR) triggering by pathogens, TLR-independent signals may be responsible for pDC activation and immune suppression in the tumor inflammatory environment.
Xiaoling Tian et al.
Journal of immunology (Baltimore, Md. : 1950), 194(8), 3873-3882 (2015-03-18)
T cells develop functional defects during HIV-1 infection, partially due to the upregulation of inhibitory receptors such as programmed death-1 (PD-1) and CTLA-4. However, the role of lymphocyte activation gene-3 (LAG-3; CD223), also known as an inhibitory receptor, in HIV
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