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Key Documents

SRP3039

Sigma-Aldrich

FGF-23 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

Sinonimo/i:

Fibroblast Growth Factor-23

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About This Item

Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Ricombinante

expressed in E. coli

Saggio

≥95% (HPLC)
≥95% (SDS-PAGE)

Forma fisica

lyophilized

PM

25.5 kDa

Confezionamento

pkg of 20 μg

tecniche

cell culture | mammalian: suitable

Impurezze

<0.1 EU/μg endotoxin, tested

Colore

white to off-white

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... FGF23(8074)

Descrizione generale

Fibroblast growth factor-23 (FGF-23) is a bone-derived hormone which is secreted by osteocytes and osteoblasts. It is part of the atypical FGF subfamily. The gene encoding it is localized on human chromosome 12p13. Recombinant human FGF-23 is a 25.5kDa globular protein containing 228 amino acid residues.

Azioni biochim/fisiol

The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. Fibroblast growth factor-23, -21 and -19 (FGF-23, FGF-21 and FGF-19) act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes cytochrome P450 family 27 subfamily B member 1 (CYP27B1) and cytochrome P450 family 24 subfamily A member 1 (CYP24A1). FGF-23 acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism.

Sequenza

MYPNASPLLG SSWGGLIHLY TATARNSYHL QIHKNGHVDG APHQTIYSAL MIRSEDAGFV VITGVMSRRY LCMDFRGNIF GSHYFDPENC RFQHQTLENG YDVYHSPQYH FLVSLGRAKR AFLPGMNPPP YSQFLSRRNE IPLIHFNTPI PRRHTRSAED DSERDPLNVL KPRARMTPAP ASCSQELPSA EDNSPMASDP LGVVRGGRVN THAGGTGPEG CRPFAKFI

Stato fisico

Lyophilized from 10 mM Sodium Acetate, pH 6.0 + 0.1 M Arginine.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Anthony A Portale et al.
PloS one, 10(11), e0142924-e0142924 (2015-11-21)
Fibroblast growth factor 23 (FGF23) is a potent regulator of phosphate (Pi) and vitamin D homeostasis. The transcription factor, early growth response 1 (egr-1), is a biomarker for FGF23-induced activation of the ERK1/2 signaling pathway. We have shown that ERK1/2
Richard G Boles
Handbook of Growth and Growth Monitoring in Health and Disease null
Interplay between vitamin D and the drug metabolizing enzyme CYP3A4.
Wang Z
The Journal of Steroid Biochemistry and Molecular Biology, 136, 54-58 (2013)
Fibroblast growth factor 23 and bone mineralisation.
Guo YC and Yuan Q
International Journal of Oral Science, 7(1), 8-13 (2015)
Klotho converts canonical FGF receptor into a specific receptor for FGF23.
Urakawa I
Nature, 444(7120), 770-774 (2006)

Articoli

Fibroblast growth factors in cell culture and various growth factors for your research

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