SML3213

Lobaplatin

≥98% (NMR)

• Sinonimo/i: Cis-[trans-1,2-cyclobutanebis(methylamine)-N,N′]-[(2S)-lactate-O1,O2)-platinum (II), D 19466, D-19466, D19466, [rel-(1R,2R)-1,2-cyclobutanedimethanamine-κN,kN′][(2S)-2-(hydroxy-kO)propanoato(2-)-kO]-, (SP-4-3)-platinum, trans-1,2-Cyclobutanedimethanamine, platinum complex
• Formula empirica (notazione di Hill): C₉H₁₈N₂O₃Pt
• Numero CAS: 135558-11-1
• Peso molecolare: 397.33
• Codice UNSPSC: 12352107
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (NMR)
• Stato: powder
• Colore: white to beige
• Solubilità: H₂O: 2 mg/mL, clear (Warmed)
• Temperatura di conservazione: −20°C
• Stringa SMILE: O=C1[O-][Pt+2]2(N[CH2]C3CCC3CN2)[O-]C1C
• InChI: 1S/C6H12N2.C3H5O3.Pt/c7-3-5-1-2-6(5)4-8;1-2(4)3(5)6;/h5-8H,1-4H2;2H,1H3,(H,5,6);/q-2;-1;+4/p-1/t;2-;/m.0./s1; HADHSETVEMCBPU-TYOUJGAFSA-M

Descrizione

Azioni biochim/fisiol

Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.

Third-generation platinum anticancer agent in vitro and in vivo.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable