SML2498

Vatalanib dihydrochloride

≥98% (HPLC)

• Sinonimo/i: 1-(4-Chloroanilino)-4-(4-pyridylmethyl)phthalazine dihydrochloride, CGP 79787 dihydrochloride, CGP 79787D dihydrochloride, N-(4-Chloroanilino)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride, PTK 787 dihydrochloride, PTK787 dihydrochloride, ZK 222584 dihydrochloride, ZK-222584 dihydrochloride, ZK222584 dihydrochloride
• Formula empirica (notazione di Hill): C₂₀H₁₅ClN₄ · 2HCl
• Numero CAS: 212141-51-0
• Peso molecolare: 419.73
• Numero MDL: MFCD08458963
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to beige
• Solubilità: H₂O: 2 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: ClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42
• InChI: 1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H; AZUQEHCMDUSRLH-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Orally active anti-angiogenic agent that targets receptor tyrosine kinases VEGFR1/2/3 (FLT-1/KDR/FLT-4), PDGFRβ, c-KIT and c-FMS.

Vatalanib (PTK787, ZK 222584, CGP 79787D, CGP 79787 succinate) is an orally active anilinophthalazine derivative that exerts its anti-angiogenic efficacy by targeting receptor tyrosine kinase (RTK) VEGFR (VEGFR1/2 IC50 = 54/39 nM; IC50 ∼30 nM against 100 ng/mL VEGF-C-induced VEGFR3 autophosphorylation in MEVCs) and, to a less extent, PDGFRβ, c-kit, c-fms (IC50 = 364, 600, 567 nM, respectively) in an ATP-competitive manner with much reduced or no potency toward >90 other kinases. Typical dosing ranges: 0.1-10 μM in cultures, 5 nM-200 μM (zebrafish) and 30-100 mg/kg (mice & rats via po. or ip) in vivo.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable