SML1561

LP-211

≥98% (HPLC)

• Sinonimo/i: 6-(4-Biphenyl-2-yl-piperazin-1-yl)-hexanoic acid 4-cyano-benzylamide, N-(4-Cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide, N-[(4-Cyanophenyl)methyl]-4-[1,1′-biphenyl]-2-yl-1-piperazinehexanamide
• Formula empirica (notazione di Hill): C₃₀H₃₄N₄O
• Numero CAS: 1052147-86-0
• Peso molecolare: 466.62
• Numero MDL: MFCD22690843
• Codice UNSPSC: 12352200
• ID PubChem: 329825965
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: film
• Colore: colorless
• Solubilità: DMSO: 5 mg/mL, clear (warmed)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C(NCC1=CC=C(C#N)C=C1)CCCCCN2CCN(C3=CC=CC=C3C4=CC=CC=C4)CC2
• InChI: 1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35); BQEDZLDNNBDKDS-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable