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Merck
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SML0088

Sigma-Aldrich

WZ811

≥98% (HPLC)

Sinonimo/i:

N1,N4-Di-2-pyridinyl-1,4-benzenedimethanamine

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About This Item

Formula empirica (notazione di Hill):
C18H18N4
Numero CAS:
55778-02-4
Peso molecolare:
290.36
Numero MDL:
MFCD18086914
Codice UNSPSC:
51111800
ID PubChem:
329825148
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to tan

Solubilità

DMSO: ≥7 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

C(Nc1ccccn1)c2ccc(CNc3ccccn3)cc2

InChI

1S/C18H18N4/c1-3-11-19-17(5-1)21-13-15-7-9-16(10-8-15)14-22-18-6-2-4-12-20-18/h1-12H,13-14H2,(H,19,21)(H,20,22)
KBVFRXIGQQRMEF-UHFFFAOYSA-N

Azioni biochim/fisiol

WZ811 is a potent, specific antagonist of CXCR4 (IC50 = 0.3 nM). WZ811 blocks SDF-1 mediated changes in cellular cAMP levels in U87 glioma cells (IC50 = 1.2 nM) and Matirgel infiltration of MDA-MB-231 cells (IC50 = 5.2 nM).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Chun-Hui Zheng et al.
Cell biology international, 42(10), 1386-1394 (2018-07-05)
CXCR4 has been shown to play a key role in the metastasis of non-small cell lung cancer (NSCLC). And CXCR may be associated with the Hippo-Yes kinase-associated protein (YAP) pathway, thus involving in the occurrence and progression of NSCLC. This
Andrew J Shepherd et al.
PloS one, 8(9), e76698-e76698 (2013-10-03)
Infection with human immunodeficiency virus-1 (HIV-1) within the brain has long been known to be associated with neurodegeneration and neurocognitive disorder (referred as HAND), a condition characterized in its early stages by declining cognitive function and behavioral disturbances. Mechanistically, the
Miodrag Dragoj et al.
Cellular oncology (Dordrecht), 40(1), 47-62 (2016-11-09)
Current high lung cancer mortality rates are mainly due to the occurrence of metastases and therapeutic resistance. Therefore, simultaneous targeting of these processes may be a valid approach for the treatment of this type of cancer. Here, we assessed relationships
Miodrag Dragoj et al.
Investigational new drugs, 35(6), 718-732 (2017-07-25)
Non-small cell lung carcinoma (NSCLC) is the most common type of lung cancer. At the time of diagnosis, a large percentage of NSCLC patients have already developed metastasis, responsible for extremely high mortality rates. CXCR4 receptor and focal adhesion kinase
Thomas A Werner et al.
British journal of cancer, 117(12), 1837-1845 (2017-11-08)
Medullary thyroid carcinoma (MTC) is a rare and challenging endocrine malignancy. Once spread, the therapeutic options are limited and the outcome poor. For these patients, the identification of new druggable biological markers is of great importance. Here, we investigated the

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