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SML0070

Sigma-Aldrich

Salsalate

≥98% (HPLC)

Sinonimo/i:

2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid

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About This Item

Formula empirica (notazione di Hill):
C14H10O5
Numero CAS:
552-94-3
Peso molecolare:
258.23
Numero CE:
209-027-4
Numero MDL:
MFCD00020252
Codice UNSPSC:
12352200
ID PubChem:
329825134
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to tan

Solubilità

DMSO: ≥15 mg/mL

Temperatura di conservazione

room temp

Stringa SMILE

OC(=O)c1ccccc1OC(=O)c2ccccc2O

InChI

1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
WVYADZUPLLSGPU-UHFFFAOYSA-N

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Applicazioni

Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

Azioni biochim/fisiol

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H361d,H412

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
071M4704V

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Salicylic acid BioXtra, ≥99.0%

Sigma-Aldrich

S5922

Salicylic acid

Martha M Rumore et al.
The Annals of pharmacotherapy, 44(7-8), 1207-1221 (2010-06-03)
To review the evidence base supporting the use of salicylates for glucose level control in patients with type 2 diabetes and provide a comprehensive review of available information describing the potential role of salicylates and, in particular, salsalate, for glucose
Allison B Goldfine et al.
Clinical and translational science, 1(1), 36-43 (2009-04-02)
Chronic subacute inflammation is implicated in the pathogenesis of insulin resistance and type 2 diabetes. Salicylates were shown years ago to lower glucose and more recently to inhibit NF-kappaB activity. Salsalate, a prodrug form of salicylate, has seen extensive clinical
Ruth C R Meex et al.
The Journal of clinical endocrinology and metabolism, 96(5), 1415-1423 (2011-02-04)
Nonsteroidal antiinflammatory drugs appear to improve insulin sensitivity and are currently tested in clinical trials. Salsalate, however, may blunt mitochondrial function, an unwarranted side effect for type 2 diabetics. We examined the effect of salsalate on ex vivo mitochondrial function
Weidong Chai et al.
Diabetes care, 34(7), 1634-1638 (2011-05-28)
Insulin recruits muscle microvasculature, thereby increasing endothelial exchange surface area. Free fatty acids (FFAs) cause insulin resistance by activating inhibitor of κB kinase β. Elevating plasma FFAs impairs insulin's microvascular and metabolic actions in vivo. Whether salsalate, an anti-inflammatory agent
Xian Wu et al.
Journal of agricultural and food chemistry, 65(33), 7200-7209 (2017-07-27)
High-fat diets (HFDs) and excess adiposity increase proinflammatory cytokines in the colon, altering gene expression in a manner that promotes the development of colorectal cancer (CRC). Thus, compounds that reduce this biochemical inflammation are potential chemopreventive agents. Curcumin (CUR), a
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