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Documenti fondamentali

SAB5500001

Sigma-Aldrich

Anti-β-Actin (ACTB) Antibody

rabbit monoclonal, SP124

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Nome del prodotto

Anti-beta-Actin antibody, Rabbit monoclonal, clone SP124, recombinant, expressed in proprietary host, affinity isolated antibody

Origine biologica

rabbit

Livello qualitativo

Ricombinante

expressed in proprietary host

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

SP124, monoclonal

Reattività contro le specie

human (tested)

Reattività contro le specie (prevista in base all’omologia)

chicken, mouse, rat, bovine, rabbit, pig, dog, hamster, frog

tecniche

flow cytometry: 1:100
immunoblotting: 1:200
immunohistochemistry: 1:200

Isotipo

IgG

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... ACTB(60)

Descrizione generale

ACTB (actin β) gene codes for β-actin. It is a cytoskeletal housekeeping protein. It is present in the cytoplasm. This gene is located on human chromosome 7p22.1.
Beta-actin is a nonmuscle cytoskeletal protein in all human cell types and is involved in cell motility, structure, and integrity. There are six different actin isoforms in human. Antibody to beta-actin provides a specific and useful tool in studying the intracellular distribution of beta-actin and the static and dynamic aspects of the cytoskeleton.

Immunogeno

Synthetic peptide near the N-terminus of human beta-Actin protein.

Applicazioni

Anti-Actin-Beta antibody has been used in western blotting.

Azioni biochim/fisiol

β-Actin modulates cell growth, migration and the G-actin pool. Mutations in ACTB leads to pleiotropic developmental disorder.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Molecular medicine reports, 19(1), 271-279 (2018-11-16)
The aim of the present study was to investigate the underlying mechanisms of hypoxia‑induced microRNA (miR)‑210 effects on mouse GC‑2spd (GC‑2) cells. GC‑2 cells were subjected to hypoxia or normoxia for 12, 24, 48 and 72 h. Apoptosis of GC‑2 cells
Nicotinic ?7 receptor inhibits the acylation stimulating protein?induced production of monocyte chemoattractant protein?1 and keratinocyte?derived chemokine in adipocytes by modulating the p38 kinase and nuclear factor??B signaling pathways
Jiao ZY, et al.
Molecular Medicine Reports, 14(4), 2959-2966 (2016)
Exosomes Derived from Squamous Head and Neck Cancer Promote Cell Survival after Ionizing Radiation
Mutschelknaus L, et al.
PLoS ONE (2016)

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

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