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Merck
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Documenti fondamentali

SAB5200600

Sigma-Aldrich

Monoclonal Anti-Git1 antibody produced in mouse

clone S39B-8, purified immunoglobulin

Sinonimo/i:

Anti-ARF GAP GIT1, Anti-CAT1, Anti-GRK-interacting protein 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

S39B-8, monoclonal

Stato

buffered aqueous solution

PM

antigen predicted mol wt 90 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

1 mg/mL

tecniche

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG1

N° accesso NCBI

NP_1140021.1

N° accesso UniProt

Q9Y2X7

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

rat ... Git1(83709)

Immunogeno

Fusion protein amino acids 375-770 (C-terminus) of rat GIT1

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Lot/Batch Number

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Antonio Totaro et al.
Molecular biology of the cell, 18(12), 5124-5138 (2007-09-28)
G-protein coupled receptor kinase-interacting protein (GIT) proteins include an N-terminal Arf GTPase-activating protein domain, and a C terminus that binds proteins regulating adhesion and motility. Given their ability to form large molecular assemblies, the GIT1 protein must be tightly regulated.
Heike Goehler et al.
Molecular cell, 15(6), 853-865 (2004-09-24)
Analysis of protein-protein interactions (PPIs) is a valuable approach for characterizing proteins of unknown function. Here, we have developed a strategy combining library and matrix yeast two-hybrid screens to generate a highly connected PPI network for Huntington's disease (HD). The
Judith Haendeler et al.
The Journal of biological chemistry, 278(50), 49936-49944 (2003-10-03)
Critical events for vasoconstrictor and growth factor signal transduction include stimulation of phospholipase Cgamma (PLCgamma) and elevation of intracellular calcium. c-Src has been proposed as a common mediator for these signals activated by both G protein-coupled receptors (GPCRs) and tyrosine
Ryan J Hoefen et al.
Journal of cell science, 119(Pt 8), 1469-1475 (2006-04-07)
The G-protein-coupled receptor (GPCR)-kinase-interacting proteins 1 and 2 (GIT1 and GIT2) are ubiquitous multidomain proteins involved in diverse cellular processes. They traffic between three distinct cellular compartments (cytoplasmic complexes, focal adhesions and the cell periphery) through interactions with proteins including
C E Turner et al.
The Journal of cell biology, 145(4), 851-863 (1999-05-20)
Paxillin is a focal adhesion adaptor protein involved in the integration of growth factor- and adhesion-mediated signal transduction pathways. Repeats of a leucine-rich sequence named paxillin LD motifs (Brown M.C., M.S. Curtis, and C.E. Turner. 1998. Nature Struct. Biol. 5:677-678)
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