Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

SAB5200074

Sigma-Aldrich

Monoclonal Anti-SCN2A1 antibody produced in mouse

clone S69-3, 1 mg/mL, purified immunoglobulin

Sinonimo/i:

Anti-NachII, Anti-Nav1.2, Anti-Nav1.2, S69-3, Anti-SCN, Anti-SCN2A, Anti-Scpll

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

mouse

Livello qualitativo

100

Coniugato

unconjugated

Forma dell’anticorpo

purified immunoglobulin

Tipo di anticorpo

primary antibodies

Clone

S69-3, monoclonal

Stato

buffered aqueous glycerol solution

PM

antigen predicted mol wt 250 kDa

Reattività contro le specie

human, rat, mouse

Concentrazione

1 mg/mL

tecniche

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG2a

N° accesso NCBI

NP_036779.1

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

rat ... Scn2a1(24766)

Descrizione generale

Sodium voltage-gated channel α subunit 2 (SCN2A1) is expressed in the axons and nerve terminals of the rat brain. The gene ID for the protein is 24766.

Specificità

Detects ~250 kDa.

Immunogeno

Fusion protein amino acids 1882-2005 (cytoplasmic C-terminus) of rat Nav1.2

Applicazioni

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Monoclonal anti-SCN2A1 antibody produced in mouse has been used for immunofluorescence and Western blotting.

Azioni biochim/fisiol

Sodium voltage-gated channel α subunit 2 (SCN2A1) may associate with a number of other proteins in the rat brain. It regulates the conductance of action potentials and also controls the release of neurotransmitters.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Ci dispiace, ma al momento non ci sono COA disponibili online per questo prodotto.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Norelle C Wildburger et al.
Molecular & cellular proteomics : MCP, 14(5), 1288-1300 (2015-03-01)
Voltage-gated sodium channels (Nav1.1-Nav1.9) are responsible for the initiation and propagation of action potentials in neurons, controlling firing patterns, synaptic transmission and plasticity of the brain circuit. Yet, it is the protein-protein interactions of the macromolecular complex that exert diverse
Je-Hyun Baek et al.
The Journal of biological chemistry, 289(22), 15363-15373 (2014-04-17)
Voltage-gated sodium (Nav) channels initiate action potentials in brain neurons and are primary therapeutic targets for anti-epileptic drugs controlling neuronal hyperexcitability in epilepsy. The molecular mechanisms underlying abnormal Nav channel expression, localization, and function during development of epilepsy are poorly
Jun Xiang et al.
Molecular medicine reports, 9(1), 16-22 (2013-11-14)
In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.