SAB4700313

Monoclonal Anti-HLA-G-Biotin antibody produced in mouse

clone MEM-G/9, purified immunoglobulin, buffered aqueous solution

• Codice UNSPSC: 12352203
• NACRES: NA.41
• Coniugato: biotin conjugate
• application: FACS
• Clone: MEM-G/9, monoclonal
• Reattività contro le specie: human
• citations: 4
• tecniche: flow cytometry: suitable

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: biotin conjugate
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: MEM-G/9, monoclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Concentrazione: 1 mg/mL
• tecniche: flow cytometry: suitable
• Isotipo: IgG1
• N° accesso NCBI: NM_002127.5
• N° accesso UniProt: P17693
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... HLA-G(3135)

Descrizione

Descrizione generale

The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.

Immunogeno

Recombinant human HLA-G refolded with beta2-microglobulin and peptide

Applicazioni

The reagent is designed for Flow Cytometry analysis of cells expressing HLA-G molecule on the cell surface using a 1:1000 dilution. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Azioni biochim/fisiol

Histocompatibility leukocyte antigen–G (HLA-G) plays an important role in preventing the activities of natural killer (NK) cell and inducing immune escape. It has the ability to block immune competent cells and innate and adaptive immune system. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

Caratteristiche e vantaggi

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Stato fisico

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable