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Key Documents

SAB4501941

Sigma-Aldrich

Anti-c-Myc Tag Antibody

rabbit polyclonal

Sinonimo/i:

Myc proto-oncogene protein, c-myc

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

product name

Anti-MYC antibody produced in rabbit, affinity isolated antibody

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 48 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:40000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... MYC(4609)

Descrizione generale

The MYC (MYC proto-oncogene, bHLH transcription factor) gene is mapped to human chromosome 8q24.21. This gene encodes an oncogenic transcription factor and belongs to the MYC gene family. Anti-MYC antibody detects endogenous levels of total MYC protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human MYC.

Immunogen Range: 386-435

Applicazioni

Anti-MYC antibody produced in rabbit has been used in western blotting.

Azioni biochim/fisiol

MYC proto-oncogene, bHLH transcription factor (MYC) is known to induce tumor growth in a variety of cancer types. c-MYC overexpression promotes DNA replication, transcription, translation and metabolism in cancer cells. Upregulation of this gene is observed in pancreatic ductal adenocarcinoma and diffuse large B-cell lymphoma (DLBCL).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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Zhaowei Xu et al.
Cell death & disease, 9(5), 559-559 (2018-05-13)
Breast cancer is a highly heterogeneous carcinoma in women worldwide, but the underlying mechanisms that account for breast cancer initiation and development have not been fully established. Mounting evidence indicates that Checkpoint suppressor 1 (CHES1) is tightly associated with tumorigenesis
c-MYC amplification and c-myc protein expression in pancreatic acinar cell carcinomas. New insights into the molecular signature of these rare cancers
La RS, et al.
Virchows Archiv, 9(5), 1-7 (2018)
PVT1 dependence in cancer with MYC copy-number increase
Tseng YY, et al.
Nature, 512(7512), 82-82 (2014)
Checkpoint suppressor 1 suppresses transcriptional activity of ERalpha and breast cancer cell proliferation via deacetylase SIRT1
Xu, Z, et al.
Cell Death & Disease, 9(5), 559-559 (2018)
MYC Protein-positive Diffuse Large B-Cell Lymphoma Features an Activated B-Cell Receptor Signal Pathway
Wang WG, et al.
American Journal of Surgical Pathology, 41(4), 541-549 (2017)

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