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SAB4200755

Sigma-Aldrich

Anti-Human IgE-Peroxidase antibody, Mouse monoclonal

clone GE-1, purified from hybridoma cell culture

Sinonimo/i:

Anti-Immunoglubulin E

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

mouse

Livello qualitativo

200

Coniugato

peroxidase conjugate

Forma dell’anticorpo

purified from hybridoma cell culture

Tipo di anticorpo

primary antibodies

Clone

GE-1, monoclonal

Stato

lyophilized powder

Reattività contro le specie

human

tecniche

ELISA: 1:20,000-1:30,000 using 5 μg/mL Human IgE myeloma for coating

Isotipo

IgG2b

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Descrizione generale

Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the GE-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgE myeloma protein. IgE (Immunoglobulin E) is the least abundant immunoglobulin isotype. IgE is produced by plasma cells and is highly functional in the lung, skin, and mucous membranes. Normal levels of IgE in serum are less than 1 μmL.

Specificità

Monoclonal Anti-Human IgE specifically recognizes Human IgE. The antibody shows no cross-reactivity with human IgG1, IgG2, IgG3, IgG4, IgA, and IgM.

Immunogeno

Purified human IgE

Applicazioni

Anti-Human IgE-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).

Azioni biochim/fisiol

IgE plays a critical role in allergic reactions and host protection from parasites. During an allergic reaction such as atopic eczema, extrinsic asthma or hay fever, fungal and parasitic infection, atopic disease, or primary immunodeficiency the serum IgE levels can be induced up to 5-fold. IgE specifically and reversibly binds to the membrane receptor Fc-epsilon receptors (FcεR) type I on the surface of basophils, eosinophils, and mast cells. This binding activates the release of histamine, leukotrienes, and other mediators responsible for hypersensitivity. The recognition and isolation of allergen-specific IgE can lead to progress in understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders.

Stato fisico

Supplied as a lyophilized powder.

Altre note

This product is for R&D use only, not for drug, household, or other uses.

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Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H317

Classi di pericolo

Skin Sens. 1

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
047M4811V
51170404

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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IgE and mast cells in allergic disease
Galli S J and Tsai M
Nature Medicine, 18(5), 693-693 (2012)
IgE and mast cells in allergic disease
Wachholz P A, et al.
Journal of Immunotoxicology, 1(3-4), 189-199 (2005)
R H Buckley et al.
The Journal of clinical investigation, 55(1), 157-165 (1975-01-01)
Concentrations of IgD and IgE were measured in sera from 165 patients with well-defined immunodeficiency in an effort to find information possibly relevant to the roles of antibodies of these classes in host defense. Values for both immunoglobulins were generally
F Zellweger et al.
Allergy, 71(12), 1652-1661 (2016-10-07)
IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality of life due to
T J Suutari et al.
Journal of investigational allergology & clinical immunology, 16(5), 296-302 (2006-10-17)
Allergic reactions to cow's milk are common in small children. One of the main protein allergens found in cow's milk is beta-lactoglobulin (beta-Lg). Reindeer and bovine milk both contain related beta-Lg proteins, but the allergenicity of reindeer beta-Lg has not
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Contatta l'Assistenza Tecnica.