SAB4200228

Anti-Glycogen Synthase 2 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• Sinonimo/i: Anti-GYS2, Anti-Glycogen synthase 2 (liver), Anti-LGS
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Forma fisica: buffered aqueous solution
• PM: antigen ~85 kDa
• Reattività contro le specie: rat, mouse
• Concentrazione: ~1.0 mg/mL
• tecniche: immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded rat liver; western blot: 1.5-3 μg/mL using mouse liver extracts (S1 fraction)
• N° accesso UniProt: P17625
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Gys2(232493)

Descrizione

Descrizione generale

Glycogen synthase 2 (GYS2) codes for a rate-limiting enzyme, glycogen synthase. The encoded protein is exclusively expressed in liver.

Immunogeno

synthetic peptide located at the C-terminus of mouse glycogen synthase 2 (GYS2), conjugated to KLH. The corresponding sequence is highly conserved in rat GYS2 (single amino acid substitution) and in human GYS2 (84% identity).

Applicazioni

Anti-Glycogen Synthase 2 antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.

Azioni biochim/fisiol

Glycogen synthase 2 (GS-2) plays a vital role as a rate limiting enzyme in glycogenesis pathway in liver and adipose tissue. It acts a target gene of peroxisome proliferator-activated receptors (PPARα, PPARβ/δ and PPARγ), which are transcription factors implicated in regulation of lipid and glucose metabolism. Mutation in the gene is associated with the pathogenesis of inherited monogenic disease glycogen storage disease 0 (GSD0).

Stato fisico

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable