SAB3500383

Anti-CXCR4 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Sinonimo/i: Anti-CXCR4
• Numero MDL: MFCD01092337
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: IgG fraction of antiserum
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: mouse, human
• tecniche: flow cytometry: suitable; immunocytochemistry: suitable; immunofluorescence: suitable; immunoprecipitation (IP): suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso NCBI: NP_003458
• N° accesso UniProt: P61073
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... CXCR4(7852)

Descrizione

Descrizione generale

C-X-C motif chemokine receptor 4 (CXCR4) is encoded by the gene mapped to human chromosome 2q22.1. The gene codes for a protein with seven transmembrane regions. The encoded protein is expressed on the surface of T-cells, B-cells, monocytes, neutrophils and dendritic cells.

Immunogeno

CXCR4 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human CXCR4.

Applicazioni

Anti-CXCR4 antibody produced in rabbit has been used in western blot analysis and indirect ELISA.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Azioni biochim/fisiol

C-X-C motif chemokine receptor 4 (CXCR4) is specific for stromal cell-derived factor-1. It plays a vital role in regulation of immune response in various immune cell types. CXCR4 interacts with CD4 (cluster of differentiation 4) and permits human immunodeficiency virus type 1 (HIV-1) entry and infection in to the cells. Polymorphism in the gene is associated with the development of Juvenile idiopathic arthritis (JIA). In addition, mutation in the gene increases the risk of susceptibility to cardiovascular diseases (CVDs).

Caratteristiche e vantaggi

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Linkage

The action of this antibody can be blocked using blocking peptide SBP3500383.

Stato fisico

Supplied in PBS with 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable