SAB3500122

Monoclonal Anti-PD-1 antibody produced in mouse

clone 7A11B1, purified immunoglobulin, buffered aqueous solution

• Sinonimo/i: Anti-CD279, Anti-PDCD-1, Anti-Programmed cell death 1
• Numero MDL: MFCD02095740
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 7A11B1, monoclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: mouse, human, rat
• tecniche: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• N° accesso UniProt: Q15116
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PDCD1(5133)

Descrizione

Descrizione generale

Programmed cell death 1 protein (PDCD1) is mapped to human chromosome 2q37.3. PDCD1 belongs to the Cluster of Differentiation 28 (CD28) family of receptors and has an immunoinhibitory domain. It is expressed in T and B lymphocytes.

Immunogeno

raised against an ~150 amino acid recombinant protein from near the terminus terminus of mouse PD-1.

Azioni biochim/fisiol

Programmed cell death 1 protein (PDCD1) modulates lymphocyte activation. Single nucleotide polymorphisms in PDCD1 is implicated in systemic lupus erythematosus, an autoimmune inflammatory disease.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrizione del bersaglio

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Stato fisico

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable