Passa al contenuto
Merck
Tutte le immagini(1)

Key Documents

View All Documentation

S8197

Sigma-Aldrich

SMER28

>99% (HPLC), solid

Sinonimo/i:

6-bromo-N-2-propenyl-4-quinazolinamine

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C11H10BrN3
Numero CAS:
307538-42-7
Peso molecolare:
264.12
Numero MDL:
MFCD02166825
Codice UNSPSC:
12352200
ID PubChem:
329824598
NACRES:
NA.77

Livello qualitativo

100

Saggio

>99% (HPLC)

Forma fisica

solid

Solubilità

DMSO: >20 mg/mL
H2O: insoluble

Temperatura di conservazione

2-8°C

Stringa SMILE

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)
BCPOLXUSCUFDGE-UHFFFAOYSA-N

Applicazioni

SMER28 may be used in mTOR-mediated signaling studies.

Azioni biochim/fisiol

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Dee Shen et al.
Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and
Ann K Rosenthal et al.
The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.