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Merck
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Documenti fondamentali

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S1195

Sigma-Aldrich

ST638

≥98% (HPLC), solid

Sinonimo/i:

α-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide

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About This Item

Formula empirica (notazione di Hill):
C19H18N2O3S
Numero CAS:
107761-24-0
Peso molecolare:
354.42
Numero MDL:
MFCD00236446
Codice UNSPSC:
12352200
ID PubChem:
329824465
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

yellow

Punto di fusione

134-135.5 °C

Solubilità

DMSO: 19 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

CCOc1cc(cc(CSc2ccccc2)c1O)\C=C(/C#N)C(N)=O

InChI

1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)/b14-8+
YKLMGKWXBLSKPK-RIYZIHGNSA-N

Azioni biochim/fisiol

Protein tyrosine kinase inhibitor (IC50 = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.

Confezionamento

Light sensitive and packaged under nitrogen.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Y Kanda et al.
Biochemical and biophysical research communications, 199(3), 1447-1452 (1994-03-30)
Thyrotropin-releasing hormone (TRH) is a well-known regulatory factor of prolactin (PRL) secretion and synthesis in lactotrophs. Recently we have found that TRH stimulates early tyrosine phosphorylation of MAP kinase in GH3 cells. Then we investigated whether tyrosine phosphorylation in TRH
A Burke-Gaffney et al.
British journal of pharmacology, 119(6), 1149-1158 (1996-11-01)
1. Tumour necrosis factor-alpha (TNF alpha) increases the expression of the adhesion molecule intercellular adhesion molecule-1 (ICAM-1) on cultured endothelial and epithelial cells and modulation of this may be important in controlling inflammation. Activation of tyrosine kinase(s) is known to
K Takenaga
Invasion & metastasis, 16(2), 97-106 (1996-01-01)
Treatment of high-metastatic Lewis lung carcinoma A11 cells with sodium orthovanadate, a phosphotyrosine phosphatase inhibitor, resulted in a dose- and time-dependent suppression of cell spreading on various extracellular matrix components such as Matrigel, fibronectin, laminin and type IV collagen, while
H Miyamoto et al.
International journal of immunopharmacology, 17(5), 433-441 (1995-05-01)
It is well known that rat basophilic leukemia cells (RBL-2H3) express high-affinity IgE receptors (Fc epsilon RI) and that the aggregation of these receptors causes the release of chemical mediators. When RBL-2H3 cells are sensitized with IgE antibody and subsequently
M Ida et al.
Biochemical pharmacology, 51(8), 1061-1067 (1996-04-26)
Pervanadate mimics several distinct insulin effects, including stimulation of hexose uptake in the in vitro system, and reduces the blood glucose level in streptozotocin-treated diabetic rats. It has been proposed that pervanadate induces insulin-like effects mediated through autophosphorylation and activation
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