PZ0302

PF-06747775

≥98% (HPLC)

• Sinonimo/i: N-[(3R,4R)-4-Fluoro-1-[6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl]-3-pyrrolidinyl]-2-propenamide, N-[(3R,4R)-4-Fluoro-1-[6-[(3-methoxy-1-methyl-1H-pyrazol-4-yl)amino]-9-methyl-9H-purin-2-yl]pyrrolidin-3-yl]acrylamide
• Formula empirica (notazione di Hill): C₁₈H₂₂FN₉O₂
• Numero CAS: 1776112-90-3
• Peso molecolare: 415.42
• Codice UNSPSC: 12352200
• ID PubChem: 329823824
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to beige
• Solubilità: DMSO: 20 mg/mL, clear
• Temperatura di conservazione: room temp
• Stringa SMILE: CN1C2=NC(N3C[C@@H](NC(C=C)=O)[C@H](F)C3)=NC(NC(C(OC)=N4)=CN4C)=C2N=C1
• InChI: 1S/C18H22FN9O2/c1-5-13(29)21-11-8-28(6-10(11)19)18-23-15(14-16(24-18)26(2)9-20-14)22-12-7-27(3)25-17(12)30-4/h5,7,9-11H,1,6,8H2,2-4H3,(H,21,29)(H,22,23,24)/t10-,11-/m1/s1; JYIUNVOCEFIUIU-GHMZBOCLSA-N

Descrizione

Azioni biochim/fisiol

PF-06747775 is an orally available, potent and selective inhibitor of the epidermal growth factor receptor) mutant form T790M (EGFR T790M inhibitor). PF-06747775 exhibits minimal activity against wild type EGFR.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable