PZ0159

MCOPPB trihydrochloride hydrate

>98% (HPLC)

• Sinonimo/i: 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole trihydrochloride hydrate
• Formula empirica (notazione di Hill): C₂₆H₄₀N₄ · 3 HCl · xH₂O
• Numero CAS: 1028969-49-4
• Peso molecolare: 518.01 (anhydrous basis)
• Codice UNSPSC: 51111800
• ID PubChem: 329823741
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: >98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to tan
• Solubilità: H₂O: ≥13 mg/mL
• Temperatura di conservazione: room temp
• Stringa SMILE: O.Cl.Cl.Cl.CC1(CCCCCCC1)N2CCC(CC2)n3c(nc4ccccc34)[C@@H]5CCCNC5
• InChI: 1S/C26H40N4.3ClH.H2O/c1-26(15-7-3-2-4-8-16-26)29-18-13-22(14-19-29)30-24-12-6-5-11-23(24)28-25(30)21-10-9-17-27-20-21;;;;/h5-6,11-12,21-22,27H,2-4,7-10,13-20H2,1H3;3*1H;1H2; UQBVSGBDJOJHIP-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

MCOPPB trihydrochloride is a potent non-peptide nociceptin/orphanin FQ peptide (NOP)-receptor full agonist [or opioid-receptor-like-1 (ORL1) receptor agonist]. MCOPPB is the most potent novel non-peptide NOP full agonist in vitro and an orally potent anxiolytic in the mice. It inhibited signaling through the NOP receptor in the mouse brain, suggesting that it penetrated into the brain after it was orally administered. It did not affect locomotor activity or memory, nor did it contribute to ethanol-induced hypnosis.

Caratteristiche e vantaggi

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable