O104

Omeprazolo

≥98% (HPLC), solid, gastric secretion inhibitor

• Sinonimo/i: 5-metossi-2-[[(4-metossi-3,5-dimetil-2-piridinil)metil]sulfinil]-1H-benzimidazolo, Antra, Losec
• Formula empirica (notazione di Hill): C₁₇H₁₉N₃O₃S
• Numero CAS: 73590-58-6
• Peso molecolare: 345.42
• Numero MDL: MFCD00083192
• Codice UNSPSC: 12352200
• ID PubChem: 24897870
• NACRES: NA.77

Proprietà

• product name: Omeprazolo, solid
• Forma fisica: solid
• Colore: white
• Solubilità: H₂O: 0.5 mg/mL; DMSO: >19 mg/mL; ethanol: 4.5 mg/mL
• Ideatore: AstraZeneca
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
• InChI: 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20); SUBDBMMJDZJVOS-UHFFFAOYSA-N
• Informazioni sul gene: human ... ABCB1(5243) , ATP4A(495) , ATP4B(496) , CYP1A2(1544)

Descrizione

Descrizione generale

Omeprazole is a benzimidazole derivative, a weak base and is lipophilic in nature. This compound is pH sensitive and does not exists in its original form at low pH.

Applicazioni

Omeprazole has been used as an atypical cytochrome P450 (CYP) 1A2 inducer in Dulbecco′s modified eagle′s medium (serum free) to study the effects of inducers on CYP activities in human hepatocytes and also to compare with other classical aryl hydrocarbon receptor ligands.

Azioni biochim/fisiol

Omeprazole binds covalently to proton pump (H⁺, K⁺-ATPase) and inhibits gastric secretion. It is useful in ameliorating the effects of peptic oesophagitis, duodenal and gastric ulcer. Omeprazole is preferred over antagonists of histamine H2-receptor and ranitidine for its higher efficiency. It is also useful in treating Zollinger-Ellison syndrome.

Caratteristiche e vantaggi

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Avvertenza

Hygroscopic, photosensitive

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317,H411
• Consigli di prudenza: P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves