P8399

Psoralen

≥99% (HPLC)

• Sinonimo/i: 6,7-Furanocoumarin, 7H-Furo[3,2-g]benzopyran-7-one, Ficusin, Furo[3,2-g]coumarin
• Formula empirica (notazione di Hill): C₁₁H₆O₃
• Numero CAS: 66-97-7
• Peso molecolare: 186.16
• Beilstein: 152784
• Numero CE: 200-639-7
• Numero MDL: MFCD00010520
• Codice UNSPSC: 12352200
• ID PubChem: 24898918
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥99% (HPLC)
• Stato: powder
• Fluorescenza: λ_ex 335 nm; λ_em 460 nm (pH 7.0)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1Oc2cc3occc3cc2C=C1
• InChI: 1S/C11H6O3/c12-11-2-1-7-5-8-3-4-13-9(8)6-10(7)14-11/h1-6H; ZCCUUQDIBDJBTK-UHFFFAOYSA-N

Descrizione

Applicazioni

Photochemical reagent for the investigation of nucleic acid structure and function.

Psoralen has been used:

• as a crosslinker for dsRNA for in- situ hybridization studies
• in testing melanin dispersal effects in fish scale melanophores
• to test its stimulatory effects in osteoblast a cell proliferation assay
• as a reference standard in high-performance liquid chromatography (HPLC)

Azioni biochim/fisiol

Psoralen belongs to the linear type furanocoumarins. It intercalates and induces interstrand cross-links in DNA. On UV exposure psoralen is excited leading to irreversible intercalation with DNA by covalent bond formation. This property of psoralen ultraviolet A light (PUVA) is exploited in treating skin diseases and cutaneous T-cell lymphoma. However, usage psoralen also leads to hepatotoxicity and cytotoxicity by the generation of psoralen photoproducts (POPs). It may be useful in treating osteoporosis

Caratteristiche e vantaggi

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Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H317
• Consigli di prudenza: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Classi di pericolo: Acute Tox. 4 Oral - Skin Sens. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves