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Key Documents

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P7527

Sigma-Aldrich

Prostaglandin E1

powder, γ-irradiated, BioXtra, suitable for cell culture

Sinonimo/i:

(11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE1

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About This Item

Formula empirica (notazione di Hill):
C20H34O5
Numero CAS:
745-65-3
Peso molecolare:
354.48
Beilstein:
5294062
Numero CE:
212-017-2
Numero MDL:
MFCD00077860
Codice UNSPSC:
12352209
ID PubChem:
24898855
NACRES:
NA.77

Origine biologica

synthetic (organic)

Livello qualitativo

200

Sterilità

γ-irradiated

Nome Commerciale

BioXtra

Forma fisica

powder

Concentrazione

≥60% (HPLC)

tecniche

cell culture | mammalian: suitable

Solubilità

ethanol: 1 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
GMVPRGQOIOIIMI-DWKJAMRDSA-N

Informazioni sul gene

human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739)
mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

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Categorie correlate

Applicazioni

For use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Prostaglandin E1 has been used in maintaining mice proximal tubule, and NRK-52E, a rat renal epithelial cell line.

Azioni biochim/fisiol

Prostaglandins mediate vasodilation and vasoconstriction, the E series of prostaglandin is a highly effective vasodilator. It is known to efficiently cause erythema. Prostaglandin E1 is considered as a potent pyretic factor, and acts through cerebral ventricles. Prostaglandin E1 is useful to prolong cardiovascular function in new born suffering from ductus-dependant congenital heart disease until surgery.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
Pediatric Cardiology, 37(1), 131-134 (2016)
Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals
Escobar C, et al.
BJU International, 100(4), 891-897 (2007)
The Prostaglandins (2013)
Stephen A Davis et al.
Nature chemical biology, 11(7), 481-487 (2015-06-02)
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Mark S Szczypka et al.
Stem cells (Dayton, Ohio), 23(1), 44-54 (2004-12-31)
Results obtained in recent experiments suggest that bone marrow-derived cells (BMDCs) engraft into tissues and differentiate into various somatic cell types. However, it is unclear whether injury is required for the phenomenon to occur at appreciable frequencies. In this study
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