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P5234

Sigma-Aldrich

Purvalanol B

≥97% (HPLC), solid

Sinonimo/i:

(2R)-2-[[6-[(3-Chloro-4-carboxyphenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol, NG 95

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About This Item

Formula empirica (notazione di Hill):
C20H25ClN6O3
Numero CAS:
212844-54-7
Peso molecolare:
432.90
Numero MDL:
MFCD04118312
Codice UNSPSC:
12352200
ID PubChem:
329820218
NACRES:
NA.77

Saggio

≥97% (HPLC)

Forma fisica

solid

Solubilità

DMSO: soluble 37 mg/mL
H2O: insoluble

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C20H25ClN6O3/c1-10(2)15(8-28)24-20-25-17(16-18(26-20)27(9-22-16)11(3)4)23-12-5-6-13(19(29)30)14(21)7-12/h5-7,9-11,15,28H,8H2,1-4H3,(H,29,30)(H2,23,24,25,26)/t15-/m0/s1
ZKDXRFMOHZVXSG-HNNXBMFYSA-N

Azioni biochim/fisiol

Purvalanol B is a cyclin-dependent; 2,6,9-substituted kinase inhibitor.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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The Multiplexed Inhibitor Bead (MIB) assay is a previously published quantitative proteomic MS-based approach to study cellular kinomes. A rather extensive procedure, need for multiple custom-made kinase inhibitors and an inability to re-use the MIB-columns, has limited its applicability. Here
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