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P5172

Sigma-Aldrich

Prostaglandin D2

≥95%, synthetic

Sinonimo/i:

(5Z,9α,13E,15S)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic-acid, PGD2

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About This Item

Formula empirica (notazione di Hill):
C20H32O5
Numero CAS:
41598-07-6
Peso molecolare:
352.47
Beilstein:
2170623
Numero MDL:
MFCD00077857
Codice UNSPSC:
12352211
eCl@ss:
42020658
ID PubChem:
24898605
NACRES:
NA.77

Origine biologica

synthetic

Livello qualitativo

100

Saggio

≥95%

Stato

powder

Temperatura di conservazione

−20°C

Stringa SMILE

[H][C@]1(C\C=C/CCCC(O)=O)[C@@H](O)CC(=O)[C@]1([H])\C=C\[C@@H](O)CCCCC

InChI

1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-18,21-22H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-/m0/s1
BHMBVRSPMRCCGG-OUTUXVNYSA-N

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Categorie correlate

Azioni biochim/fisiol

Primary prostaglandin in brain; induces inflammation; stimulates adenylyl cyclase.

Caratteristiche e vantaggi

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Health hazardExclamation mark
GHS08,GHS07

Avvertenze

Danger

Indicazioni di pericolo

H302,H360

Classi di pericolo

Acute Tox. 4 Oral - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
MKCQ9648
MKCQ4174
MKCP0239
MKCD7725
MKBZ7060V

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Sigma-Aldrich

538904

Prostaglandin E2

Prostaglandin I2 sodium salt ≥96% (HPLC), synthetic, powder

Sigma-Aldrich

P6188

Prostaglandin I2 sodium salt

Prostaglandin E1 ≥98% (HPLC), synthetic

Sigma-Aldrich

P5515

Prostaglandin E1

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid ~100 μg/mL in ethanol, ≥90% (HPLC)

Sigma-Aldrich

H3023

20-Hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acid

Roy Pettipher et al.
Nature reviews. Drug discovery, 6(4), 313-325 (2007-03-31)
Immunological activation of mast cells is an important trigger in the cascade of inflammatory events leading to the manifestation of allergic diseases. Pharmacological studies using the recently discovered DP(1) and CRTH2 antagonists combined with genetic analysis support the view that
S O'Sullivan et al.
The Journal of allergy and clinical immunology, 98(2), 421-432 (1996-08-01)
Prostaglandin (PG)D2 is a major product of arachidonic acid metabolism in pulmonary mast cells. We therefore attempted to determine whether measurement of the stable urinary metabolite of PGD2, 9 alpha, 11 beta-PGF2, could serve as a marker of mast cell
Takahisa Murata et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), 5205-5210 (2013-03-13)
We investigated the role of prostaglandin D2 (PGD2) signaling in acute lung injury (ALI), focusing on its producer-effector interaction in vivo. Administration of endotoxin increased edema and neutrophil infiltration in the WT mouse lung. Gene disruption of hematopoietic PGD synthase
E E Nishizawa et al.
Prostaglandins, 9(1), 109-121 (1975-01-01)
Prostaglandin D2 was found to be a potent inhibitor of platelet aggregation. Aggregation of human platelets by ADP, collagen and prostaglandin G2 was inhibited more strongly by PGD2 than by PGE1. Although ADP-induced aggregation of rabbit platelets was inhibited more
Hana Sarashina et al.
Journal of immunology (Baltimore, Md. : 1950), 192(1), 459-465 (2013-12-04)
The effects of PGD2 are extremely context dependent. It can have pro- or anti-inflammatory effects in clinically important pathological conditions. A greater mechanistic insight into the determinants of PGD2 activity during inflammation is thus required. In this study, we investigated
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