P5117

Anti-Peripherin antibody, Mouse monoclonal

clone 8G2, purified from hybridoma cell culture

• Sinonimo/i: Anti-NEF4, Anti-PRPH1
• Numero MDL: MFCD01633973
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: purified from hybridoma cell culture
• Tipo di anticorpo: primary antibodies
• Clone: 8G2, monoclonal
• Forma fisica: buffered aqueous solution
• Reattività contro le specie: rat, bovine, pig, mouse, rabbit, feline, human
• tecniche: immunohistochemistry: suitable; indirect ELISA: suitable; microarray: suitable; western blot: 0.5-1.0 μg/mL using total cell extract from rat PC12 cells
• Isotipo: IgG1
• N° accesso UniProt: P41219
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... PRPH(5630) ; mouse ... Prph(19132) ; rat ... Prph(24688)

Descrizione

Descrizione generale

Monoclonal Anti-Peripherin (mouse IgG1 isotype) is derived from the 8G2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with the full-length recombinant rat peripherin. Peripherin was originally identified as a neuronal intermediate filament protein-(IF) is thought to be expressed only in the peripheral nervous system (PNS).

Peripherin is an intermediate filament protein. It is expressed in peripheral and enteric neurons. The gene encoding this protein is localized on rat chromosome 7.

Immunogeno

full-length recombinant rat peripherin.

Applicazioni

Anti-Peripherin antibody, Mouse monoclonal has been used in:

• immunohistochemistry
• western blotting
• enzyme linked immunosorbent assay (ELISA)
• immunofluorescence staining

Azioni biochim/fisiol

Peripherin is upregulated during pheochromocytoma PC12 cell differentiation. Later studies have detected peripherin also in certain central nervous system (CNS) neurons.

eripherin has been linked with axonal extension and regeneration of nerve fibers. It also has a role in neurite outgrowth propagation. Peripherin is a substrate of protein kinase B/Akt. Phosphorylation of this protein is induced after nerve injury.

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable