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Key Documents

Altri documenti

P0928

Sigma-Aldrich

Resorufin pentyl ether

Sinonimo/i:

7-Pentyloxy-3-phenoxazone, 7-Pentyloxy-3H-phenoxazin-3-one, O7-Pentylresorufin, Pentoxyresorufin

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About This Item

Formula empirica (notazione di Hill):
C17H17NO3
Numero CAS:
87687-03-4
Peso molecolare:
283.32
Beilstein:
8394939
Numero MDL:
MFCD00037664
Codice UNSPSC:
12161501
ID PubChem:
24898138
NACRES:
NA.47

Saggio

≥98% (TLC)

Livello qualitativo

200

Forma fisica

powder

Solubilità

acetonitrile: 0.95- 1.05 mg/mL, clear, orange

Temperatura di conservazione

2-8°C

Stringa SMILE

CCCCCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3
ZPSOKQFFOYYPKC-UHFFFAOYSA-N

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Descrizione generale

Resorufin pentyl ether is an analog of resazurin. Resorufin is a redox probe which is colorless and non-fluorescent in its reduced state. On oxidation, it fluoresces red. Resorufin is used widely as an indicator in microbiological media. It can be used to differentiate between actively metabolizing cells and inactive or dead cells.

Applicazioni

Resorufin pentyl ether has been used as a substrate to study the effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes.

Azioni biochim/fisiol

Fluorimetric substrate for cytochrome P450 linked enzymes, CYP2B and CYP2B4.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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A Pietersma et al.
Free radical research, 28(2), 137-150 (1998-06-30)
The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells. Experimental evidence has implicated the
Microbial Biofilms null
V Burkina et al.
Ecotoxicology and environmental safety, 79, 148-152 (2012-01-17)
Little is known about the effects of the cardiovascular drug verapamil (VRP) on metabolic processes in fish. Most calcium channel blockers including VRP are metabolized by cytochrome P450 (CYP450) enzymes. In this study we investigated the in vivo effect of
Modulatory effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes
Catheleeya Mekjaruskul
Journal of Ethnopharmacology, 141(3) (2012)
E S Tzanakakis et al.
Cell motility and the cytoskeleton, 48(3), 175-189 (2001-02-27)
Cultured rat hepatocytes self-assemble into three-dimensional structures or spheroids that exhibit ultrastructural characteristics of native hepatic tissue and enhanced liver-specific functions. The spheroid formation process involves cell translocation and changes in cell shape, indicative of the reorganization of the cytoskeletal
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Articoli

Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

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