O1383

Acido oleico

suitable for cell culture, BioReagent

• Sinonimo/i: Acido cis-9-ottadecenoico, Acido elainico
• Formula condensata: CH₃(CH₂)₇CH=CH(CH₂)₇COOH
• Numero CAS: 112-80-1
• Peso molecolare: 282.46
• Beilstein: 1726542
• Numero CE: 204-007-1
• Numero MDL: MFCD00064242
• Codice UNSPSC: 12352211
• ID PubChem: 24897941
• NACRES: NA.75

Proprietà

• Origine biologica: palm oil
• Livello qualitativo: 200
• Tensione di vapore: 1 mmHg ( 176 °C)
• Nome Commerciale: BioReagent
• Saggio: ≥99% (GC)
• Stato: viscous liquid
• tecniche: cell culture | mammalian: suitable
• Indice di rifrazione: n20/D 1.459 (lit.)
• P. ebollizione: 194-195 °C/1.2 mmHg (lit.)
• Punto di fusione: 13-14 °C (lit.)
• Solubilità: ethanol: soluble
• Densità: 0.89 g/mL at 25 °C (lit.); 0.89 g/mL at 25 °C (lit.)
• Temperatura di conservazione: −20°C
• Stringa SMILE: CCCCCCCC\C=C/CCCCCCCC(O)=O
• InChI: 1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9-; ZQPPMHVWECSIRJ-KTKRTIGZSA-N
• Informazioni sul gene: human ... SOAT1(6646) , SOAT2(8435)

Descrizione

Descrizione generale

Oleic acid is a mono-unsaturated omega-9 fatty acid created by dehydrogenation of stearic acid. It is then further dehydrogenated and elongated to create members of the n-9 family of fatty acids. Oleic acid is not an essential fatty acid (EFA); however, providing it to cells in culture reduces energy demand.

Oleic acid mediates complete oxidation of fatty acid in sirtuin1- proliferator-activated receptor γ coactivator−1α (SIRT1-PGC-1α) signalling pathway. Oleic acid shows anti-inflammatory properties related to atherosclerosis and insulin resistant state. Oleic acid inhibits permeability in gap junctions and promotes glucose uptake in astrocytes. Oleic acid aids in neural cell proliferation by increasing glucose uptake and by protein kinase C (PKC) activation. Oleic acid is essential for axonal growth and neuronal clustering.

Applicazioni

Oleic acid has been used:

• in fatty acid oxidation rate experiments in myotubes and in Sirt1 enzyme assay
• to determine quantitatively its effect on lipid droplets by optical diffraction tomography
• as a fatty acid source in the medium for primary hepatocyte culture

Confezionamento

Sealed ampule.

Avvertenza

Unsaturated fatty acids are subject to oxidation and peroxidation. Consider complexed fatty acid supplements.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Dispositivi di protezione individuale: Eyeshields, Gloves, type ABEK (EN14387) respirator filter