N7758

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

• Formula empirica (notazione di Hill): C₁₉H₂₁NO₄ · HCl · 2H₂O
• Numero CAS: 51481-60-8
• Peso molecolare: 399.87
• Beilstein: 6260807
• Numero MDL: MFCD00150901
• Codice UNSPSC: 12352200
• ID PubChem: 24278050
• NACRES: NA.77

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (TLC and titration)
• Forma fisica: powder
• Attività ottica: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• Colore: white to off-white
• Solubilità: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1; TXMZWEASFRBVKY-IOQDSZRYSA-N
• Informazioni sul gene: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Descrizione

Applicazioni

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Azioni biochim/fisiol

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Caratteristiche e vantaggi

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Avvertenza

Light sensitive.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves