N3510
Niclosamide
Sinonimo/i:
2′,5-Dichloro-4′-nitrosalicylanilide
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About This Item
Formula empirica (notazione di Hill):
C13H8Cl2N2O4
Numero CAS:
Peso molecolare:
327.12
Beilstein:
2820605
Numero CE:
Numero MDL:
Codice UNSPSC:
51102829
ID PubChem:
NACRES:
NA.85
Prodotti consigliati
Stato
powder
Livello qualitativo
Spettro attività antibiotica
parasites
Modalità d’azione
enzyme | inhibits
Stringa SMILE
Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+]([O-])=O
InChI
1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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Categorie correlate
Applicazioni
Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.
Azioni biochim/fisiol
Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.
Altre note
50g,250g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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