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M8750

(+)-Methamphetamine hydrochloride

Name: (+)-Methamphetamine hydrochloride
Brand: SIGMA

Sinonimo/i:

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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About This Item

Formula empirica (notazione di Hill):

C₁₀H₁₅N · HCl

Numero CAS:

51-57-0

Peso molecolare:

185.69

Numero CE:

200-106-9

Numero MDL:

MFCD00056130

Codice UNSPSC:

12352116

ID PubChem:

24897282

NACRES:

NA.77

Controllo stupefacenti

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Solubilità

H₂O: soluble
ethanol: soluble

applicazioni

forensics and toxicology
pharmaceutical (small molecule)
veterinary

Ideatore

Teva

Stringa SMILE

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1
TWXDDNPPQUTEOV-FVGYRXGTSA-N

Informazioni sul gene

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

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Categorie correlate

Analytical Chemistry

Analytical Chromatography

Chromatography Standards

Controlled Substances & Illicit Drug Standards

Reference Materials

Azioni biochim/fisiol

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Caratteristiche e vantaggi

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Altre note

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pittogrammi

GHS06

Avvertenze

Danger

Indicazioni di pericolo

H300,H336

Consigli di prudenza

P301 + P310 + P330

Classi di pericolo

Acute Tox. 2 Oral - STOT SE 3

Organi bersaglio

Central nervous system

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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Spontaneous locomotor activity and pharmacokinetics of intravenous methamphetamine and its metabolite amphetamine in the rat.

G J Rivière et al.

The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)

The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3

REM sleep deprivation impairs retrieval, but not reconsolidation, of methamphetamine reward memory in male rats.

Kaveh Shahveisi et al.

Pharmacology, biochemistry, and behavior, 185, 172759-172759 (2019-08-16)

Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be

The C-Terminal Domain of LRRK2 with the G2019S Substitution Increases Mutant A53T α-Synuclein Toxicity in Dopaminergic Neurons In Vivo.

Noémie Cresto et al.

International journal of molecular sciences, 22(13) (2021-07-03)

Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the

Withdrawal from long-term methamphetamine self-administration 'normalizes' neurometabolites in rhesus monkeys: a (1) H MR spectroscopy study.

Shaolin Yang et al.

Addiction biology, 20(1), 69-79 (2013-08-06)

(1) H magnetic resonance spectroscopy has demonstrated alterations in several neurometabolites in methamphetamine (METH)-dependent individuals in brain regions implicated in addiction. Yet, it is unclear whether these neurochemicals return to homeostatic levels after an individual abstains from drug use, a

Modafinil improves methamphetamine-induced object recognition deficits and restores prefrontal cortex ERK signaling in mice.

Betina González et al.

Neuropharmacology, 87, 188-197 (2014-02-18)

Chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans and in animal models. Modafinil is a wake-promoting compound approved for the treatment of sleeping disorders. It is also prescribed off label to treat METH dependence. In the

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