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Key Documents

M5324

Sigma-Aldrich

PX 12

≥98% (HPLC), powder

Sinonimo/i:

2-[(1-methylpropyl)dithio]-1H-imidazole

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About This Item

Formula empirica (notazione di Hill):
C7H12N2S2
Numero CAS:
Peso molecolare:
188.31
Numero MDL:
Codice UNSPSC:
12352200
ID PubChem:
NACRES:
NA.77

Livello qualitativo

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

off-white to tan

Solubilità

DMSO: >25 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

CCC(C)SSc1ncc[nH]1

InChI

1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
BPBPYQWMFCTCNG-UHFFFAOYSA-N

Applicazioni

PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.

Azioni biochim/fisiol

PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).

Pittogrammi

Exclamation mark

Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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