Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

L8397

Sigma-Aldrich

ʟ-Leucinethiol

leucine aminopeptidase inhibitor, solid

Sinonimo/i:

Dithiobis(2-amino-4-methylpentane)

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(1)

About This Item

Formula empirica (notazione di Hill):
C12H28N2S2 · 2HCl
Numero CAS:
88264-65-7
Peso molecolare:
337.42
Numero MDL:
MFCD00133441
Codice UNSPSC:
12352202
ID PubChem:
24278518
NACRES:
NA.77

Nome del prodotto

L-Leucinethiol, oxidized dihydrochloride, leucine aminopeptidase inhibitor

Livello qualitativo

200

Stato

solid

Temperatura di conservazione

−20°C

Stringa SMILE

CC(C)C[C@H](N)CS

InChI

1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1
GXEDNWSUKCJLLB-LURJTMIESA-N

Applicazioni

Upon reduction in vivo to L-leucinethiol, compound is a potent inhibitor of leucine aminopeptidase.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
080H1020

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

T D Ocain et al.
Journal of medicinal chemistry, 31(11), 2193-2199 (1988-11-01)
Sulfur-containing amino acid and peptide analogues of bestatin [((2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl)-L-leucine] (1) have been synthesized and evaluated as inhibitors of aminopeptidase M (AP-M), leucine aminopeptidase (LAP), and aminopeptidase B (AP-B). The 2-thiolbestatin analogue (6) was found to be a potent inhibitor of
W W Chan
Biochemical and biophysical research communications, 116(1), 297-302 (1983-10-14)
L-leucinthiol (2-amino-4-methyl-1-pentanethiol) was designed as an inhibitor of leucine aminopeptidase by analogy with sulfhydryl inhibitors of other zinc-containing peptidases. It was synthesized from L-leucinol and shown to be a potent competitive inhibitor of the microsomal aminopeptidase from porcine kidney (Ki
D S Pickering et al.
Archives of biochemistry and biophysics, 239(2), 368-374 (1985-06-01)
L-Leucinthiol, a synthetic derivative of mercaptoethylamine with a hydrophobic side chain, was recently reported to be a potent inhibitor of microsomal aminopeptidase. The structural features necessary for interaction of mercaptoamines with this enzyme have now been explored more systematically. Optimal
T D Ocain et al.
Biochemical and biophysical research communications, 145(3), 1038-1042 (1987-06-30)
L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much
Kathrin Textoris-Taube et al.
European journal of immunology, 50(2), 270-283 (2019-11-16)
Dissecting the different steps of the processing and presentation of tumor-associated antigens is a key aspect of immunotherapies enabling to tackle the immune response evasion attempts of cancer cells. The immunodominant glycoprotein gp100209-217 epitope, which is liberated from the melanoma
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.