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L7895

Sigma-Aldrich

Lipopolysaccharides from Salmonella typhosa

γ-irradiated, BioXtra, suitable for cell culture

Sinonimo/i:

LPS

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About This Item

Numero MDL:
Codice UNSPSC:
12352201
NACRES:
NA.75

Origine biologica

bacterial (Salmonella typhosa)

Livello qualitativo

Sterilità

γ-irradiated

Nome Commerciale

BioXtra

Forma fisica

lyophilized powder

Purificato mediante

gel-filtration chromatography

tecniche

cell culture | mammalian: suitable

Impurezze

<1% Protein (Lowry)

Colore

white to faint yellow

Solubilità

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

Temperatura di conservazione

2-8°C

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Applicazioni

Lipopolysaccharides from Salmonella typhosa are used in cell culture and cell binding applications. The role of LPS in the secretion of TNF-α and IL-6 was studied in mouse spleen cell culture. It was used to study the role of inflammatory responses in multiple sclerosis.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Azioni biochim/fisiol

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Altre note

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulence factor of Mycobacterium tuberculosis, and modification of the terminal arabinan residues of this compound with mannose caps (producing mannosyl-capped LAM [ManLAM]) in M. tuberculosis or with phosphoinositol
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The great complexity of many human pathologies, such as cancer, diabetes, and neurodegenerative diseases, requires new tools for studies of biological processes on the whole organism level. The discovery of novel biocompatible reactions has tremendously advanced our understanding of basic
Johnathan Ho et al.
PLoS biology, 14(10), e2000117-e2000117 (2016-10-26)
STAT2 is the quintessential transcription factor for type 1 interferons (IFNs), where it functions as a heterodimer with STAT1. However, the human and murine STAT2-deficient phenotypes suggest important additional and currently unidentified type 1 IFN-independent activities. Here, we show that
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The number of patients with mental illnesses is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. It is suggested that inflammatory molecules derived from microglia play crucial roles for the pathophysiology of depression. In the
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The Journal of biological chemistry, 277(5), 3065-3068 (2001-12-14)
We demonstrate that lipopolysaccharide-induced tumor necrosis factor (TNF) biosynthesis becomes independent of MAPKAP kinase 2 (MK2) when the AU-rich element (ARE) of the TNF gene is deleted. In spleen cells and macrophages where TNF biosynthesis is restored as a result

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