L6785

Lactacystin

≥90% (HPLC), powder, proteosome inhibitor

• Formula empirica (notazione di Hill): C₁₅H₂₄N₂O₇S
• Numero CAS: 133343-34-7
• Peso molecolare: 376.43
• Numero MDL: MFCD01076525
• Codice UNSPSC: 12352200
• ID PubChem: 24896445
• NACRES: NA.77

Proprietà

• product name: Lactacystin, ≥90% (HPLC)
• Livello qualitativo: 200
• Saggio: ≥90% (HPLC)
• Forma fisica: powder
• Potenza: 4 nM K_i (proteasome inhibitor)
• Solubilità: water: 10 mg/mL, clear, colorless
• Temperatura di conservazione: −20°C
• Stringa SMILE: CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
• InChI: 1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1; DAQAKHDKYAWHCG-RWTHQLGUSA-N

Descrizione

Descrizione generale

Lactacystin is an antibiotic and a metabolite of Streptomyces spp.

Applicazioni

Lactacystin has been used:

• as a proteasome inhibitor to inhibit protein degradation
• to inhibit proteasomal activity of cells for live cell imaging
• to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
• to provide unilateral injection to animals to induce nigrostriatal lesions

Azioni biochim/fisiol

Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor for clasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)