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Key Documents

L1645

Sigma-Aldrich

Anti-Human Lambda Light Chain (Bound and Free) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.46

Origine biologica

goat

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

secondary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

tecniche

indirect ELISA: 1:2,500

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

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Descrizione generale

Immunoglobulins (Ig) are produced by the B cells and play crucial role in host humoral immune response. A typical immunoglobulin consists of two heavy chains and two light chains. The two light chains are either κ or the λ chain. The B cells express one type of light chain during their life time.
Lambda (λ) light chain comprises an amino-terminal variable region and carboxy-terminal constant region. λ chain is biologically critical and constitutes up to 30 to 40% of human immunoglobulin (Ig) molecules. The human λ locus is mapped to the chromosome location 22.

Applicazioni

Anti-Human Lambda Light Chain (Bound and Free) antibody has been used in surface plasmon resonance assay.
Anti-Human Lambda Light Chain (bound and free) antibody produced in goat has been used in indirect enzyme linked immuno sorbent assay (ELISA).

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative

Stoccaggio e stabilità

For continuous use, store at 2-8 °C for up to one month.For extended storage, solution may be frozen inworking aliquots. Repeated freezing and thawing is notrecommended. Storage in "frost-free" freezers is notrecommended.If slight turbidity occurs upon prolonged storage, clarify by centrifugation before use.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


Certificati d'analisi (COA)

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An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease
MAbs, 10(4), 664-677 (2018)
Structural and functional properties of human lambda-light-chain variable-region subgroups.
A Solomon et al.
Clinical and diagnostic laboratory immunology, 2(4), 387-394 (1995-07-01)
Adam W Clarke et al.
mAbs, 10(4), 664-677 (2018-02-14)
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blockade of the TL1A pathway has been shown to reduce inflammatory responses while leaving baseline immunity intact, and to be
Jerry A Katzmann et al.
Clinical chemistry, 48(9), 1437-1444 (2002-08-27)
The detection of monoclonal free light chains (FLCs) is an important diagnostic aid for a variety of monoclonal gammopathies and is especially important in light-chain diseases, such as light-chain myeloma, primary systemic amyloidosis, and light-chain-deposition disease. These diseases are more

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