K2389

Kainic acid monohydrate

≥98% (HPLC), from Digenea simplex

• Sinonimo/i: 2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
• Formula empirica (notazione di Hill): C₁₀H₁₅NO₄ · H₂O
• Numero CAS: 58002-62-3
• Peso molecolare: 231.25
• Numero MDL: MFCD00150833
• Codice UNSPSC: 12352106
• ID PubChem: 24724520
• NACRES: NA.77

Proprietà

• Origine biologica: Digenea simplex
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white
• Solubilità: H₂O: >10 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O
• InChI: 1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1; FZNZRJRSYLQHLT-SLGZUKMRSA-N

Descrizione

Applicazioni

Kainic acid monohydrate has been used:

• As a convulsant to induce epileptogenesis and epilepsy in mice.
• To stimulate in vitro excitotoxic trauma in spiral ganglion neurons on inner hair cells.
• To induce seizures in rat model.
• To induce status epilepticus in adult male Wistar rats.

Azioni biochim/fisiol

Ionotropic glutamate receptors form ion channels, and conduct Na⁺ and K⁺ fluxes. The receptors possess an agonist binding site and it encounters a conformational change upon agonist binding to it. Kainate gated channels participate in glutamate-induced excitatory postsynaptic neuronal potential.

Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)