K0890

Anti-Potassium Channel K_V11.3 (erg3)

affinity isolated antibody, lyophilized powder

• Sinonimo/i: Anti-KCNH7, Anti-ether-a-go-go-related channel 3
• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: lyophilized powder
• Reattività contro le specie: mouse, human, rat
• tecniche: immunohistochemistry: suitable using rat brain sections; western blot: 1:300 using rat brain lysates
• N° accesso UniProt: Q9NS40
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... KCNH7(90134) ; mouse ... Kcnh7(170738) ; rat ... Kcnh7(170739)

Descrizione

Descrizione generale

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7), also referred to as erg3, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K⁺ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the apical membrane of the retinal pigment epithelium.

Specificità

The K_V11.3 antibody is directed against an intracellular epitope of C-terminal part of K_V11.3.

Immunogeno

synthetic peptide CPEFLDLEKSKLKSKE corresponding to amino acids 1108-1123 of rat K_V11.3.

Azioni biochim/fisiol

The gene Kcnh7 (potassium voltage-gated channel subfamily H member 7) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. In the nervous system, it may participate in the regulation of neuronal excitability. The erg3 channels have relatively negative activation threshold compared to erg1 and erg2. They are capable of recycling K⁺ ions to the subretinal space in the dark and contribute to the maintenance of the resting membrane potential.

Stato fisico

Lyophilized powder containing phosphate buffered saline, pH 7.4, 1% BSA and 0.025% sodium azide.

Ricostituzione

Reconstitute the lyophilized vial with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids