C1740
Complement component C1q from human serum
≥95% (SDS-PAGE)
Sinonimo/i:
C1q from human serum
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About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Saggio
≥95% (SDS-PAGE)
Forma fisica
liquid
tecniche
activity assay: suitable
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
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Descrizione generale
C1q, together with C1r and C1s, in the ratio of 1:2:2, form the C1 complex which is the first component of the classical complement pathway. C1q is composed of 18 polypeptide chains (six A, six B, six C) (MW 460 kDa). All contain an 81-aa collagen-like region composed of (Gly-Xaa-Yaa) repeating sequences close to the N-terminus. Three chains (A1B1C1) form a triple helix with the C-terminus forming the globular heads which may be structurally and functionally distinct domains.
Applicazioni
Complement component C1q is an important regulator factor for platelet activation. This has been a topic for research, as platelet-leukocyte aggregates play an important role in inflammatory conditions such as coronary heart disease. In particular, C1q has been shown to inhibit collagen induced aggregation and enhance production of reactive oxygen species (ROS).
Azioni biochim/fisiol
C1q deficiency, either because of rare homozygous genetic defect, or transcriptional/translational defects, is almost certainly a cause of systemic lupus erythematosus (SLE). The three C1q subunits are expressed through a novel mechanism of transcriptional synchronization.
Stato fisico
Supplied as a solution in 10 mM HEPES, 300 mM NaCl, pH 7.2
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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