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Documenti fondamentali

I3525

Sigma-Aldrich

Interleukin-17A human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinonimo/i:

CTLA-8, IL-17

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About This Item

Numero MDL:
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

Ricombinante

expressed in E. coli

Saggio

≥98% (SDS-PAGE)

Stato

lyophilized powder

Potenza

≤2.0 ng/mL ED50

PM

31 kDa

Confezionamento

pkg of 50 μg

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested (endotoxin level is less than 0.1 ng per μg cytokine (1 EU/μg).)

N° accesso UniProt

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... IL17A(3605)

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Azioni biochim/fisiol

IL-17, initially known as CTLA-8, is a T cell-expressed polypeptide that appears to be involved in the regulation of the hematopoietic system. IL-17 has been shown to induce IL-6, IL-8, and G-CSF production by fibroblasts; all of these cytokines have demonstrated effects on hematopoiesis.

Stato fisico

Lyophilized with no additives.

Risultati analitici

  • The biological activity of human IL-17 is measured by its ability to induce IL-6 production using NHDF cells.
  • Biological activity is also determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50 is < 2.0 ng/ml, corresponding to a specific activity of > 5 x 105 units/mg.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)


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Lin Fan et al.
PloS one, 10(5), e0127087-e0127087 (2015-05-29)
Th1 cells play an essential role in immune protection against tuberculosis. Th17 cells might be involved with immune pathology in active human tuberculosis (TB). The balance between Th1 and Th17 cells in patients with cavitary tuberculosis needs to be clarified
Yan Jin et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 52(10), 981-988 (2015-08-25)
There has been significant interest in the association between asthma and the polymorphisms of IL-17A and IL-17F for a period of time. This work aims to present a clearer relationship between asthma and the polymorphisms of IL-17A and IL-17F. Searches
W T Qi et al.
Genetics and molecular research : GMR, 14(4), 13364-13369 (2015-11-05)
We conducted a study to investigate the role of three IL-17 gene single nucleotide polymorphisms (SNP) (rs2275913G>A, rs3748067C>T, and rs763780 T>C) in the development of gastric cancer. A total of 252 patients with gastric cancer and 252 control subjects were
J Y Wang et al.
Allergy, 64(7), 1056-1060 (2009-02-13)
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of
Hye-Lin Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(33), E3422-E3431 (2014-08-06)
Psoriasis is a chronic inflammatory skin disease characterized by abnormal keratinocyte proliferation and differentiation and by an influx of inflammatory cells. The mechanisms underlying psoriasis in humans and in mouse models are poorly understood, although evidence strongly points to crucial

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