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H5257

Sigma-Aldrich

Hispidin

solid, ≥98% (HPLC)

Sinonimo/i:

6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Formula empirica (notazione di Hill):
C13H10O5
Numero CAS:
555-55-5
Peso molecolare:
246.22
Numero MDL:
MFCD01866972
Codice UNSPSC:
12352200
ID PubChem:
24278468
NACRES:
NA.77

Origine biologica

synthetic (organic)

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

solid

Condizioni di stoccaggio

protect from light

Colore

yellow to brown

Punto di fusione

237.5-238.5  °C

Solubilità

DMSO: >10 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+
SGJNQVTUYXCBKH-HNQUOIGGSA-N

Informazioni sul gene

human ... PRKACB(5567) , PRKAR2B(5577) , PRKCB(5579)

Descrizione generale

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Azioni biochim/fisiol

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
026M4610V
092M4633V
067K46001
067K4600
015K46003

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Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
Guan-Jhong Huang et al.
Journal of agricultural and food chemistry, 59(10), 5702-5706 (2011-04-02)
The inhibitory activity from the isolated component of the fruiting body Phellinus merrillii (PM) was evaluated against α-glucosidase and lens aldose reductase from Sprague-Dawley male rats and compared to the quercetin as an aldose reductase inhibitor and acarbose as an
C Gonindard et al.
Cell biology and toxicology, 13(3), 141-153 (1997-03-01)
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy)
Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
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